Hanafy Abeer, Aldawsari Hibah M, Badr Jihan M, Ibrahim Amany K, Abdel-Hady Seham El-Sayed
Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Evid Based Complement Alternat Med. 2016;2016:4579149. doi: 10.1155/2016/4579149. Epub 2016 Mar 16.
The methanol extract of the fruit pulp of Adansonia digitata L. (Malvaceae) was examined for its hepatoprotective activity against liver damage induced by acetaminophen in rats. The principle depends on the fact that administration of acetaminophen will be associated with development of oxidative stress. In addition, hepatospecific serum markers will be disturbed. Treatment of the rats with the methanol extract of the fruit pulp of Adansonia digitata L. prior to administration of acetaminophen significantly reduced the disturbance in liver function. Liver functions were measured by assessment of total protein, total bilirubin, ALP, ALT, and AST. Oxidative stress parameter and antioxidant markers were also evaluated. Moreover, histopathological evaluation was performed in order to assess liver case regarding inflammatory infiltration or necrosis. Animals were observed for any symptoms of toxicity after administration of extract of the fruit pulp of Adansonia digitata L. to ensure safety of the fruit extract.
对猴面包树（锦葵科）果肉的甲醇提取物进行了研究，以考察其对大鼠扑热息痛诱导的肝损伤的保肝活性。其原理基于这样一个事实，即给予扑热息痛会伴随着氧化应激的产生。此外，肝脏特异性血清标志物也会受到干扰。在给予扑热息痛之前，用猴面包树果肉的甲醇提取物处理大鼠，可显著减轻肝功能的紊乱。通过评估总蛋白、总胆红素、碱性磷酸酶、谷丙转氨酶和谷草转氨酶来测定肝功能。还评估了氧化应激参数和抗氧化标志物。此外，进行了组织病理学评估，以评估肝脏的炎症浸润或坏死情况。在给予猴面包树果肉提取物后，观察动物是否有任何毒性症状，以确保果实提取物的安全性。
