Hirose Asuka, Terauchi Masakazu, Akiyoshi Mihoko, Owa Yoko, Kato Kiyoko, Kubota Toshiro
Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo, Tokyo, 113-8510 Japan.
Department of Women's Health, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo, Tokyo, 113-8510 Japan.
Biopsychosoc Med. 2016 Apr 26;10:12. doi: 10.1186/s13030-016-0066-4. eCollection 2016.
Oxidative stress is known to be a factor in various diseases. In this study, we investigated whether physical and psychological symptoms of menopause, cardiovascular parameters, body composition, and lifestyle factors are associated with oxidative stress in middle-aged women.
This cross-sectional study used baseline data collected in a previous study that examined the effects of a dietary supplement on a variety of health parameters in 95 women aged 40 to 60 years. Participants had been assessed for age, menopausal status, body composition, cardiovascular parameters, physical and psychological symptoms of menopause, and lifestyle factors. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) level, an oxidative stress marker, had also been measured. Dichotomizing 8-OHdG levels as low (≤25 ng/mg creatinine) and high (>25 ng/mg creatinine), we sought to identify the health parameters that are associated with high 8-OHdG level.
Women with a high 8-OHdG level had lower body weight, lower body mass index, lower body fat mass, higher body temperature, scored higher for both anxiety and depression on the Hospital Anxiety and Depression Scale (HADS), and consumed more alcohol. Multiple logistic regression analysis revealed that the HADS-depression subscale (HADS-D) score was the sole independent contributor to high 8-OHdG level (adjusted odds ratio, 1.23 per point increase in HADS-D score; 95 % confidence interval, 1.06-1.45).
Depressive symptom score was shown to be independently associated with high 8-OHdG level in middle-aged women, suggesting a link between mood disorder and oxidative stress.
UMIN-CTR UMIN000009353.
氧化应激是多种疾病的一个影响因素。在本研究中，我们调查了中年女性的更年期身体和心理症状、心血管参数、身体成分及生活方式因素是否与氧化应激相关。
这项横断面研究使用了先前一项研究收集的基线数据，该研究调查了一种膳食补充剂对95名40至60岁女性多种健康参数的影响。对参与者进行了年龄、绝经状态、身体成分、心血管参数、更年期身体和心理症状以及生活方式因素的评估。还测量了氧化应激标志物尿8-羟基-2'-脱氧鸟苷（8-OHdG）水平。将8-OHdG水平分为低（≤25 ng/mg肌酐）和高（>25 ng/mg肌酐）两组，我们试图确定与高8-OHdG水平相关的健康参数。
8-OHdG水平高的女性体重较低、体重指数较低、体脂肪量较低、体温较高，在医院焦虑抑郁量表（HADS）上的焦虑和抑郁得分较高，且饮酒量较多。多因素logistic回归分析显示，HADS抑郁分量表（HADS-D）得分是高8-OHdG水平的唯一独立影响因素（调整优势比，HADS-D得分每增加1分，优势比为1.23；95%置信区间，1.06-1.45）。
抑郁症状得分被证明与中年女性高8-OHdG水平独立相关，提示情绪障碍与氧化应激之间存在联系。
UMIN-CTR UMIN000009353
