Jeppesen Anne S, Soelberg Jens, Jäger Anna K
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2 Universitetsparken, 2100 Copenhagen, Denmark.
NaturMedicinsk Museum, Faculty of Health and Medical Sciences, University of Copenhagen, 2 Universitetsparken, 2100 Copenhagen, Denmark.
Plants (Basel). 2012 Oct 24;1(2):74-81. doi: 10.3390/plants1020074.
Plants used to treat inflammatory ailments, pain, fever and infections in the Pamir Mountains in northeastern Afghanistan, were tested for antibacterial and COX-1 inhibitory activity. Water and ethanol extracts of 20 species were tested for antibacterial activity against two gram positive and two gram negative bacteria. The ethanol extract of Arnebia guttata inhibited Staphylococcus aureus with a MIC of 6 µg/mL. Water and ethanol extracts of Ephedra intermedia and the ethanol extracts of Lagochilus cabulicus and Peganum harmala inhibited Staphylococcus aureus at 0.5 mg/mL, and the P. harmala extract further inhibited the growth of Bacillus subtilis and E. coli, also with MICs of 0.5 mg/mL. Ethanol extracts of Artemisia persica (IC50: 0.5 µg/mL), Dragocephalum paulsenii (IC50: 0.5 µg/mL), Ephedra intermedia (IC50: 3.8 µg/mL), Hyoscyamus pusillus, Nepeta parmiriensis (IC50: 0.7 µg/mL) and Rumex patientia subsp. pamiricus (IC50: 3.5 µg/mL) exhibited COX-1 inhibitory activity. The observed in vitro activities support the use of some of the plant species in the traditional medicine systems of the Pamir Mountains.
对阿富汗东北部帕米尔山脉用于治疗炎症性疾病、疼痛、发烧和感染的植物进行了抗菌和COX - 1抑制活性测试。对20种植物的水提取物和乙醇提取物进行了针对两种革兰氏阳性菌和两种革兰氏阴性菌的抗菌活性测试。新疆紫草的乙醇提取物对金黄色葡萄球菌有抑制作用，最低抑菌浓度（MIC）为6微克/毫升。中麻黄的水提取物和乙醇提取物、卡布唇萼薄荷和骆驼蓬的乙醇提取物在浓度为0.5毫克/毫升时对金黄色葡萄球菌有抑制作用，且骆驼蓬提取物还能抑制枯草芽孢杆菌和大肠杆菌的生长，其MIC也为0.5毫克/毫升。桃叶蒿（IC50：0.5微克/毫升）、保氏青兰（IC50：0.5微克/毫升）、中麻黄（IC50：3.8微克/毫升）、矮小天仙子、帕米尔荆芥（IC50：0.7微克/毫升）和帕米尔酸模亚种（IC50：3.5微克/毫升）的乙醇提取物表现出COX - 1抑制活性。观察到的体外活性支持了帕米尔山脉传统医学系统中对某些植物物种的使用。
