筛选祖鲁药用植物中的前列腺素合成抑制剂。
Screening of Zulu medicinal plants for prostaglandin-synthesis inhibitors.
作者信息
Jäger A K, Hutchings A, van Staden J
机构信息
Department of Botany, University of Natal Pietermarizburg, Scottsville, South Africa.
出版信息
J Ethnopharmacol. 1996 Jun;52(2):95-100. doi: 10.1016/0378-8741(96)01395-5.
Aqueous and ethanolic extracts of 39 plants used in traditional Zulu medicine to treat headache or inflammatory diseases were screened for prostaglandin-synthesis inhibitors. Extracts were tested in an in vitro assay for cyclooxygenase inhibitors. In general, ethanolic extracts caused higher inhibition than aqueous extracts. Two-thirds of the plants screened had high inhibitory activity. The highest inhibition was obtained with ethanolic extracts of Bidens pilosa, Eucomis autumnalis, Harpephyllum caffrum, Helichrysum nudifolium, Leonotis intermedia, L. leonorus, Ocotea bullata, Rumex saggitatus, Solanum mauritianum, Synadenium cupulare and Trichilia dregeana.
对用于祖鲁族传统医学治疗头痛或炎症性疾病的39种植物的水提取物和乙醇提取物进行了前列腺素合成抑制剂筛选。提取物在体外进行环氧化酶抑制剂检测。一般来说，乙醇提取物的抑制作用比水提取物更强。三分之二被筛选的植物具有高抑制活性。毛鬼针草、秋绵枣儿、南非酒果、裸叶蜡菊、中间狮子草、狮子草、紫铆、箭叶酸模、毛茄、杯腺大戟和德氏地黄连的乙醇提取物表现出最高的抑制作用。
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