MacKay R J, French T W, Nguyen H T, Mayhew I G
Am J Vet Res. 1983 May;44(5):774-80.
The effects of large doses of phenylbutazone were evaluated in clinically normal horses. The drug was given to 4 groups of 2 horses each at the rate of 30 mg/kg of body weight, orally, or 30, 15, or 8 mg/kg IV daily for up to 2 weeks. All horses became anorectic and depressed after 2 to 4 phenylbutazone treatments, and the horses given 15 or 30 mg/kg died on or between days 4 and 7 of treatment. A decrease in total blood neutrophil count occurred in all horses, and was associated with toxic left shift in horses given the 2 larger dosage schedules. The horses also had progressive increases in serum urea nitrogen, creatinine, and phosphorus concentrations, accompanied by decreasing serum calcium concentrations. There was a progressive decrease in total serum protein in all 8 horses. Gastrointestinal ulcerations, renal papillary necrosis, and vascular thromboses were the predominant postmortem findings.
在临床正常的马匹中评估了大剂量保泰松的效果。将该药物以30毫克/千克体重的剂量口服给予4组，每组2匹马，或以每日30、15或8毫克/千克的剂量静脉注射，持续2周。在进行2至4次保泰松治疗后，所有马匹均出现食欲不振和精神沉郁，给予15或30毫克/千克剂量的马匹在治疗的第4至7天或在此期间死亡。所有马匹的全血中性粒细胞计数均下降，并且在给予较大剂量方案的马匹中出现毒性左移。这些马匹的血清尿素氮、肌酐和磷浓度也逐渐升高，同时血清钙浓度降低。所有8匹马的血清总蛋白均逐渐下降。胃肠道溃疡、肾乳头坏死和血管血栓形成是主要的尸检发现。
