Glasbrenner B, Pieramico O, Brecht-Krauss D, Baur M, Malfertheiner P
Abteilung Innere Medizin I, Universität Ulm.
Clin Investig. 1993 Jul;71(7):542-6. doi: 10.1007/BF00208478.
The purpose of this study was to determine whether obese patients have different rates of solid and liquid gastric emptying compared to healthy controls. Twenty-four obese patients (7 males, 17 females) were investigated prior to dietary restriction. The patients had a weight excess above ideal weight ranging from 25% to 216% (mean weight 118.1 +/- 6.5 kg). The control group consisted of 8 healthy subjects (4 males, 4 females), within 10% of the ideal weight. The solid phase of the test meal consisted of 40 g bread, 30 g ham, 10 g margarine, and two scrambled eggs labeled with 99mTc. For the liquid phase, 200 ml orange juice was labeled with 201Tl. Three-minute counts of both tracers were taken for 106 min using a large field-of-view gamma camera. In obese patients, a significantly shortened lag phase for the emptying of solids was observed (27.0 +/- 3.3 versus 38.4 +/- 4.1 min; P < 0.05). Half-emptying time (105.9 +/- 6.7 versus 100.7 +/- 5.7 min), emptying rate (0.60 +/- 0.04 versus 0.71 +/- 0.07%/min), and total emptying of solids (49.4 +/- 3.6 versus 50.5 +/- 5.0%) were not different from controls. Obese subjects had a trend to slowed liquid emptying (half-time 82.7 +/- 4.8 versus 69.9 +/- 6.9 min; emptying rate 0.59 +/- 0.03 versus 0.65 +/- 0.03%/min; total emptying 59.8 +/- 2.9 versus 66.0 +/- 3.3%), but this was not statistically significant. There was no correlation between weight or body surface area and rate of solid or liquid gastric emptying.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是确定肥胖患者与健康对照相比，固体和液体胃排空率是否存在差异。24名肥胖患者（7名男性，17名女性）在饮食限制前接受了调查。患者体重超过理想体重的范围为25%至216%（平均体重118.1±6.5千克）。对照组由8名健康受试者（4名男性，4名女性）组成，体重在理想体重的10%以内。测试餐的固体相包括40克面包、30克火腿、10克人造黄油和两个用99mTc标记的炒鸡蛋。液体相为200毫升用201Tl标记的橙汁。使用大视野γ相机对两种示踪剂进行106分钟的3分钟计数。在肥胖患者中，观察到固体排空的延迟期显著缩短（27.0±3.3对38.4±4.1分钟；P<0.05）。半排空时间（105.9±6.7对100.7±5.7分钟）、排空率（0.60±0.04对0.71±0.07%/分钟）和固体的总排空率（49.4±3.6对50.5±5.0%）与对照组无差异。肥胖受试者有液体排空减慢的趋势（半衰期82.7±4.8对69.9±6.9分钟；排空率0.59±0.03对0.65±0.03%/分钟；总排空率59.8±2.9对66.0±3.3%），但这在统计学上无显著意义。体重或体表面积与固体或液体胃排空率之间无相关性。（摘要截断于250字）
