Petramfar Peyman, Moein Mahmoodreza, Samani Soliman Mohammadi, Tabatabaei Sayed Hamidreza, Zarshenas Mohammad M
Clinical Neurology Research Center, Neurology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
Medicinal Plants Processing Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
Neurol Sci. 2016 Sep;37(9):1449-55. doi: 10.1007/s10072-016-2600-3. Epub 2016 May 11.
A four-week, double-blind, randomized, placebo-controlled trial was conducted to assay the effectiveness of Ajwain 10 % (Trachyspermum ammi Sprague) topical cream on neuropathic pain. Intervention encompassed Ajwain 10 % and placebo creams. Ninety-two patients who specifically mentioned daily and nocturnal burning feet were randomly assigned to receive one of those interventions. Presence and decline in patients' numbness, tingling and allodynia were also evaluated. Major outcome measure was alteration in feet burning intensity (final week versus baseline week) regarding to a visual analog scale on a 0-10 cm scale (0 being "no pain", 10 being "worst pain"). Significant reduction in feet burning scores as well as numbness, tingling and allodynia were found in Ajwain group compared to placebo. This trial examining a cream of Ajwain essential oil versus placebo revealed the significance difference between two groups. This medicament can be a good candidate for the alleviation of feet burning, a neuropathic complication.
进行了一项为期四周的双盲、随机、安慰剂对照试验，以测定10%阿育吠陀（印度藏茴香）外用乳膏对神经性疼痛的疗效。干预措施包括10%阿育吠陀乳膏和安慰剂乳膏。92名特别提到有每日和夜间足部灼痛的患者被随机分配接受其中一种干预措施。还评估了患者麻木、刺痛和感觉异常的存在及减轻情况。主要结局指标是根据0至10厘米视觉模拟量表（0表示“无疼痛”，10表示“最剧烈疼痛”）评估足部灼痛强度（最后一周与基线周相比）的变化。与安慰剂组相比，阿育吠陀组的足部灼痛评分以及麻木、刺痛和感觉异常均有显著降低。这项比较阿育吠陀精油乳膏与安慰剂的试验揭示了两组之间的显著差异。这种药物可能是缓解足部灼痛（一种神经性并发症）的良好候选药物。
