精油成分的类阿片样活性。
Analgesic-like activity of essential oils constituents.
机构信息
Department of Physiology, Federal University of Sergipe, CEP 49100-000, São Cristóvão, SE, Brazil.
出版信息
Molecules. 2011 Mar 7;16(3):2233-52. doi: 10.3390/molecules16032233.
Research on neuroactive drugs is a pharmaceutical sector of high interest and growth. The discovery of efficient drugs that can relieve pain is a subject of research in the pharmaceutical industry and academic field because pain is a symptom of many diseases. This review will summarize results on the discovery of essential oil constituents with analgesic-like activity from the chemical and pharmacological perspectives. Overall, 43 bioactive compounds were selected in nociception models. Among them, 62.8% were monoterpenes, 18.6% sesquiterpenes and other constituents represented 18.6%. The data show the potential of this group of natural product chemicals as analgesic drugs that may be useful for therapeutic purposes.
神经活性药物的研究是一个非常有兴趣和增长潜力的制药领域。发现能够缓解疼痛的有效药物是制药行业和学术领域的研究课题，因为疼痛是许多疾病的症状。这篇综述将从化学和药理学的角度总结具有类似镇痛活性的精油成分的发现结果。总的来说，在伤害感受模型中选择了 43 种具有生物活性的化合物。其中，62.8%为单萜，18.6%为倍半萜，其他成分占 18.6%。这些数据显示了这组天然产物化学物质作为可能对治疗有帮助的镇痛药物的潜力。
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