人胰岛素：一种线粒体信号肽作为空腹血糖相关氧化应激受损的生物标志物。
Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress.
作者信息
Voigt Annet, Jelinek Herbert F
机构信息
Department of Biochemistry, Freie Universität Berlin, Berlin, Germany School of Community Health and Centre for Research in Complex Systems, Charles Sturt University, Bathurst, Australia.
School of Community Health and Centre for Research in Complex Systems, Charles Sturt University, Bathurst, Australia Division of Cardiology, Australian School of Advanced Medicine, Macquarie University, Sydney, Australia
出版信息
Physiol Rep. 2016 May;4(9). doi: 10.14814/phy2.12796.
Mitochondrial RNR-2 (mt-RNR2, humanin) has been shown to play a role in protecting several types of cells and tissues from the effects of oxidative stress. Humanin (HN) functions through extracellular and intracellular pathways adjusting mitochondrial oxidative phosphorylation and ATP production. Addition of HN improved insulin sensitivity in animal models of diabetes mellitus but no clinical studies have been carried out to measure HN levels in humans associated with hyperglycemia. The plasma levels of HN in participants attending a diabetes complications screening clinic were measured. Clinical history and anthropometric data were obtained from all participants. Plasma levels of HN were measured by a commercial ELISA kit. All data were analyzed applying nonparametric statistics and general linear modeling to correct for age and gender. A significant decrease (P = 0.0001) in HN was observed in the impaired fasting glucose (IFG) group (n = 23; 204.84 ± 92.87 pg mL(-1)) compared to control (n = 58; 124.3 ± 83.91 pg mL(-1)) consistent with an adaptive cellular response by HN to a slight increase in BGL.
线粒体核糖核苷酸还原酶2（mt-RNR2，人胰岛素）已被证明在保护多种类型的细胞和组织免受氧化应激影响方面发挥作用。人胰岛素（HN）通过细胞外和细胞内途径发挥作用，调节线粒体氧化磷酸化和ATP生成。在糖尿病动物模型中添加HN可改善胰岛素敏感性，但尚未开展临床研究来测量与高血糖相关的人类HN水平。对参加糖尿病并发症筛查门诊的参与者的血浆HN水平进行了测量。收集了所有参与者的临床病史和人体测量数据。使用商用ELISA试剂盒测量血浆HN水平。所有数据采用非参数统计和一般线性模型进行分析，以校正年龄和性别因素。与对照组（n = 58；124.3 ± 83.91 pg mL⁻¹）相比，空腹血糖受损（IFG）组（n = 23；204.84 ± 92.87 pg mL⁻¹）的HN水平显著降低（P = 0.0001），这与HN对血糖水平轻微升高的适应性细胞反应一致。
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