高效上转换纳米复合材料在活体中的光声/发光/磁共振多模态成像。
Deep Photoacoustic/Luminescence/Magnetic Resonance Multimodal Imaging in Living Subjects Using High-Efficiency Upconversion Nanocomposites.
机构信息
State Key Laboratory of Molecular Vaccinology and Molecular Diagnosis and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, P. R. China.
Department of Biomaterials and Fujian Provincial Key Laboratory of Fire Retardant Materials, College of Materials, Xiamen University, Xiamen, 361005, P. R. China.
出版信息
Adv Mater. 2016 Aug;28(30):6411-9. doi: 10.1002/adma.201506460. Epub 2016 May 17.
A gadolinium-doped multi-shell upconversion nanoparticle under 800 nm excitation is synthesized with a 10-fold fluorescence-intensity enhancement over that under 980 nm. The nanoformulations exhibit excellent photoacoustic/luminescence/magnetic resonance tri-modal imaging capabilities, enabling visualization of tumor morphology and microvessel distribution at a new imaging depth.
一种掺钆多壳层上转换纳米粒子在 800nm 激发下的荧光强度比 980nm 激发下增强了 10 倍。这些纳米制剂表现出优异的光声/荧光/磁共振三模态成像能力，使肿瘤形态和微血管分布的可视化达到了新的成像深度。
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