Diniz Michelle Dos Santos, Bavoso Nádia Couto, Kakehasi Adriana Maria, Lauria Márcio Weissheimer, Soares Maria Marta Sarquis, Machado-Pinto Jackson
Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
An Bras Dermatol. 2016 Apr;91(2):150-5. doi: 10.1590/abd1806-4841.20164082.
Obesity is considered a chronic low-grade inflammatory disease that shares mediators of inflammation with psoriasis, such as TNF-α and IL-6. The relationship between these two conditions involves factors such as predisposition and response to therapy, in addition to an association with cardiovascular disease.
The aim of the present study was to investigate the prevalence of adiposity as determined by body mass index (BMI), waist circumference (WC), and dual energy X-ray absorptiometry (DXA) evaluation in patients with psoriasis.
BMI, WC and body composition by DXA were measured in 42 psoriatic patients without joint complaints and in 41 control patients using standard procedures. In the comparison between cases and controls, we used Pearson's Χ2 test or Fisher's exact test, and the nonparametric Mann-Whitney test. The difference between the diverse classification methods for obesity was evaluated using McNemar's test. To test the level of agreement between those variables, we used the weighted kappa coefficient.
There was no difference in the prevalence of obesity among cases and controls. Both BMI and WC had low agreement with measures of body fat evaluated by DXA. With the use of DXA scanning, prevalence of overweight and obesity in patients with psoriasis was 83.3%, which constitutes a strong evidence of the need for intervention on this metabolic parameter.
Dual energy X-ray absorptiometry was more capable of identifying obesity compared with BMI and WC both in psoriatic and control patients.
肥胖被认为是一种慢性低度炎症性疾病，与银屑病共享炎症介质，如肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）。这两种疾病之间的关系涉及易感性和对治疗的反应等因素，此外还与心血管疾病有关。
本研究的目的是调查银屑病患者中由体重指数（BMI）、腰围（WC）和双能X线吸收法（DXA）评估所确定的肥胖患病率。
采用标准程序，对42例无关节症状的银屑病患者和41例对照患者测量BMI、WC和通过DXA测定的身体成分。在病例组和对照组的比较中，我们使用Pearson卡方检验或Fisher精确检验以及非参数Mann-Whitney检验。使用McNemar检验评估肥胖不同分类方法之间的差异。为了检验这些变量之间的一致性水平，我们使用加权kappa系数。
病例组和对照组的肥胖患病率没有差异。BMI和WC与通过DXA评估的体脂测量值的一致性都很低。通过DXA扫描，银屑病患者中超重和肥胖的患病率为83.3%，这有力地证明了对这一代谢参数进行干预的必要性。
与BMI和WC相比，双能X线吸收法在银屑病患者和对照患者中都更能识别肥胖。
