Duarte Gleison Vieira, Follador Ivonise, Cavalheiro Carolina M Alves, Silva Thadeu S, Oliveira Maria de Fátima S P de
Universidade Federal da Bahia, Salvador, BA, Brasil.
An Bras Dermatol. 2010 May-Jun;85(3):355-60. doi: 10.1590/s0365-05962010000300009.
Recent studies have found a relationship between obesity and chronic inflammation, confirmed by the association of high levels of tumor necrosis factor (TNF-_), interleukin six (IL-6,) and reactive C-protein with an increase in body mass index (BMI). In obese individuals, this inflammatory condition could contribute to the development or aggravation of psoriasis. Analogous phenomena have already been described in other inflammatory chronic diseases, such as rheumatoid arthritis and Crohn's disease. Epidemiological studies have identified a high prevalence of cardiovascular comorbidities, secondary to the metabolic alterations associated with psoriasis and obesity. A few aspects of this association remain unclear, such as the impact of obesity in the clinical forms of dermatoses, in the response to treatment, and its relationship with comorbidities.
近期研究发现肥胖与慢性炎症之间存在关联，这一点通过肿瘤坏死因子（TNF-α）、白细胞介素6（IL-6）及C反应蛋白水平升高与体重指数（BMI）增加之间的相关性得到证实。在肥胖个体中，这种炎症状态可能促使银屑病的发生或加重。类似现象在其他慢性炎症性疾病中也已有描述，如类风湿关节炎和克罗恩病。流行病学研究已证实，继发于银屑病和肥胖相关代谢改变的心血管合并症患病率较高。这种关联的一些方面仍不明确，如肥胖对皮肤病临床类型、治疗反应的影响及其与合并症的关系。
