采用新方法评估多发性骨髓瘤患者的血清硫醇/二硫键平衡。
Assessment of serum thiol/disulfide homeostasis in multiple myeloma patients by a new method.
机构信息
a Department of Hematology , Turkiye Yuksek Ihtisas Training and Research Hospital , Ankara , Turkey.
b Department of Internal Medicine , Ataturk Training and Research Hospital , Ankara , Turkey.
出版信息
Redox Rep. 2017 Nov;22(6):246-251. doi: 10.1080/13510002.2016.1180100. Epub 2016 May 19.
OBJECTIVES
The etiology of multiple myeloma (MM) is not exactly known. This study investigated the role of thiol/disulfide homeostasis in the etiopathogenesis of MM.
METHODS
Some 50 patients with MM (aged 39-84 years) and 50 sex-matched healthy volunteer controls (aged 50-91 years) participated in this study. Venous blood samples were collected, and levels of native thiols, total thiols, and disulfide were measured.
RESULTS
Native and total thiol levels in the control group were determined to be higher than in the study and patient groups (P<0.001). Disulfide levels were found to be higher in the control group than in the study group and higher in newly diagnosed patients than in outpatients who were undergoing treatment (P=0.002). The ratios of thiol levels were found to be similar in both the study and control groups (P>0.05).
DISCUSSION
The results of the study show that although there was a decrease in the levels of disulfide, native thiol, and total thiol, the balance of thiol/disulfide was maintained. This is the first study to research the homeostasis of dynamic thiol/disulfide from the perspective of the new method that was used. We hope that this study will encourage and facilitate further studies in this area.
目的
多发性骨髓瘤（MM）的病因尚不完全清楚。本研究探讨了巯基/二硫键动态平衡在 MM 发病机制中的作用。
方法
本研究纳入了 50 名 MM 患者（年龄 39-84 岁）和 50 名性别匹配的健康志愿者对照（年龄 50-91 岁）。采集静脉血样，测定内源性巯基、总巯基和二硫键水平。
结果
对照组的内源性巯基和总巯基水平高于研究组和患者组（P<0.001）。对照组的二硫键水平高于研究组，初诊患者的二硫键水平高于正在接受治疗的门诊患者（P=0.002）。研究组和对照组的巯基水平比值相似（P>0.05）。
讨论
研究结果表明，尽管二硫键、内源性巯基和总巯基水平下降，但巯基/二硫键的平衡得以维持。这是首次从所使用的新方法的角度研究动态巯基/二硫键的动态平衡。我们希望这项研究将鼓励和促进该领域的进一步研究。
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