• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Long lasting respiratory depression induced by morphine-6-glucuronide?吗啡-6-葡萄糖醛酸诱导的长期呼吸抑制？
Br J Clin Pharmacol. 1989 Apr;27(4):515-8. doi: 10.1111/j.1365-2125.1989.tb05401.x.
2
Morphine-6-glucuronide: morphine's successor for postoperative pain relief?吗啡-6-葡萄糖醛酸：吗啡用于术后镇痛的继任者？
Anesth Analg. 2006 Jun;102(6):1789-97. doi: 10.1213/01.ane.0000217197.96784.c3.
3
Morphine-6-glucuronide (M6G) for postoperative pain relief.吗啡-6-葡萄糖醛酸苷（M6G）用于术后疼痛缓解。
Eur J Pain. 2008 May;12(4):403-11. doi: 10.1016/j.ejpain.2007.07.009. Epub 2007 Sep 14.
4
Morphine-6-glucuronide, an active morphine metabolite for the potential treatment of post-operative pain.吗啡-6-葡萄糖醛酸，一种用于潜在治疗术后疼痛的活性吗啡代谢物。
Curr Opin Investig Drugs. 2008 Jul;9(7):786-99.
5
A randomised controlled trial on the efficacy and side-effect profile (nausea/vomiting/sedation) of morphine-6-glucuronide versus morphine for post-operative pain relief after major abdominal surgery.一项关于吗啡-6-葡糖苷酸与吗啡用于大型腹部手术后缓解术后疼痛的疗效和副作用（恶心/呕吐/镇静）的随机对照试验。
Eur J Pain. 2011 Apr;15(4):402-8. doi: 10.1016/j.ejpain.2010.09.007. Epub 2010 Oct 30.
6
Efficacy and safety of morphine-6-glucuronide (M6G) for postoperative pain relief: a randomized, double-blind study.吗啡-6-葡萄糖醛酸苷（M6G）用于术后镇痛的有效性和安全性：一项随机双盲研究。
Eur J Pain. 2009 Mar;13(3):293-9. doi: 10.1016/j.ejpain.2008.04.015. Epub 2008 Jun 11.
7
Respiratory depression following morphine and morphine-6-glucuronide in normal subjects.正常受试者使用吗啡及吗啡 -6- 葡萄糖醛酸苷后的呼吸抑制。
Br J Clin Pharmacol. 1995 Aug;40(2):145-52.
8
A randomized, double-blind, placebo-controlled pilot study of IV morphine-6-glucuronide for postoperative pain relief after knee replacement surgery.一项关于静脉注射吗啡-6-葡萄糖醛酸酯用于膝关节置换术后疼痛缓解的随机、双盲、安慰剂对照的试点研究。
Clin J Pain. 2007 Mar-Apr;23(3):197-203. doi: 10.1097/AJP.0b013e31802b4f6a.
9
Plasma concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide and their relationship with analgesia and side effects in patients with cancer-related pain.癌症相关疼痛患者血浆中吗啡、吗啡 - 6 - 葡萄糖醛酸苷和吗啡 - 3 - 葡萄糖醛酸苷的浓度及其与镇痛和副作用的关系。
Palliat Med. 2003 Mar;17(2):185-90. doi: 10.1191/0269216303pm658oa.
10
Diffusion of morphine-6-beta-D-glucuronide into the neonatal guinea pig brain during drug-induced respiratory depression.
J Pharmacol Exp Ther. 1994 Oct;271(1):118-24.

引用本文的文献

1
Comparison of Relative Activity versus Relative Expression Factors (RAF versus REF) in Predicting Glucuronidation Mediated Drug Clearance Using Recombinant UGTs.使用重组 UGT 预测葡萄糖醛酸化介导的药物清除率时，相对活性与相对表达因子（RAF 与 REF）的比较。
Pharm Res. 2024 Aug;41(8):1621-1630. doi: 10.1007/s11095-024-03750-x. Epub 2024 Aug 6.
2
[Differential therapeutic aspects of analgesia with oral sustained-release strong opioids: application intervals, metabolism and immunosuppression].[口服缓释强效阿片类药物镇痛的差异治疗方面：用药间隔、代谢与免疫抑制]
Schmerz. 2008 Oct;22(5):562, 564-8, 570. doi: 10.1007/s00482-008-0657-5.
3
Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives.阿片类镇痛药临床反应的遗传预测因素：临床应用及未来展望。
Clin Pharmacokinet. 2004;43(14):983-1013. doi: 10.2165/00003088-200443140-00003.
4
Morphine-6-glucuronide: an analgesic of the future?吗啡-6-葡萄糖醛酸：未来的镇痛药？
Clin Pharmacokinet. 2001;40(7):485-99. doi: 10.2165/00003088-200140070-00001.
5
Pharmacokinetics of opioids in liver disease.阿片类药物在肝脏疾病中的药代动力学。
Clin Pharmacokinet. 1999 Jul;37(1):17-40. doi: 10.2165/00003088-199937010-00002.
6
Pharmacokinetic and pharmacodynamic principles of illicit drug use and treatment of illicit drug users.非法药物使用的药代动力学和药效学原理以及非法药物使用者的治疗
Clin Pharmacokinet. 1997 Nov;33(5):344-400. doi: 10.2165/00003088-199733050-00003.
7
The role of beta-glucuronidase in drug disposition and drug targeting in humans.β-葡萄糖醛酸酶在人体药物处置和药物靶向中的作用。
Clin Pharmacokinet. 1997 Jul;33(1):18-31. doi: 10.2165/00003088-199733010-00003.
8
Plasma concentrations and renal clearance of morphine, morphine-3-glucuronide and morphine-6-glucuronide in cancer patients receiving morphine.接受吗啡治疗的癌症患者体内吗啡、吗啡 - 3 - 葡萄糖醛酸苷和吗啡 - 6 - 葡萄糖醛酸苷的血浆浓度及肾清除率
Clin Pharmacokinet. 1993 May;24(5):413-20. doi: 10.2165/00003088-199324050-00005.
9
Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations.吗啡在人体内的药代动力学与代谢。肠肝循环及代谢产物对活性阿片类药物浓度的相对贡献。
Clin Pharmacokinet. 1993 Apr;24(4):344-54. doi: 10.2165/00003088-199324040-00007.
10
Morphine glucuronidation in premature neonates.早产儿体内吗啡的葡萄糖醛酸化作用。
Br J Clin Pharmacol. 1993 Mar;35(3):314-7.

本文引用的文献

1
Determination of morphine, morphine-3-glucuronide and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography.采用离子对高效液相色谱法测定血浆和尿液中的吗啡、吗啡-3-葡萄糖醛酸苷以及（初步测定）吗啡-6-葡萄糖醛酸苷。
J Chromatogr. 1982 Jul 9;230(2):427-32. doi: 10.1016/s0378-4347(00)80494-6.
2
Patient-controlled analgesic therapy, Part IV: pharmacokinetics and analgesic plasma concentrations of morphine.
Clin Pharmacokinet. 1982 May-Jun;7(3):266-79. doi: 10.2165/00003088-198207030-00006.
3
Steady-state kinetics and analgesic effect of oral morphine in cancer patients.
Eur J Clin Pharmacol. 1983;24(4):537-42. doi: 10.1007/BF00609900.
4
Quantitation of clonazepam and its 7-amino and 7-acetamido metabolites in plasma by high-performance liquid chromatography.高效液相色谱法定量测定血浆中氯硝西泮及其7-氨基和7-乙酰氨基代谢物
J Chromatogr. 1984 Mar 9;306:241-8. doi: 10.1016/s0378-4347(00)80886-5.
5
Meperidine-associated myoclonus and seizures in long-term hemodialysis patients.长期血液透析患者中与哌替啶相关的肌阵挛和癫痫发作。
Ann Neurol. 1983 Nov;14(5):593. doi: 10.1002/ana.410140520.
6
Analgesic effect of morphine glucuronides.吗啡葡萄糖醛酸苷的镇痛作用。
Tohoku J Exp Med. 1971 Sep;105(1):45-52. doi: 10.1620/tjem.105.45.
7
Morphine pharmacokinetics in early infancy.
Anesthesiology. 1987 Feb;66(2):136-9. doi: 10.1097/00000542-198702000-00005.
8
Renal failure does not impair the metabolism of morphine.肾衰竭不会损害吗啡的代谢。
Br J Clin Pharmacol. 1986 Jul;22(1):55-9. doi: 10.1111/j.1365-2125.1986.tb02880.x.
9
Kinetics of morphine in patients with renal failure.肾衰竭患者吗啡的动力学
Eur J Clin Pharmacol. 1987;32(4):377-82. doi: 10.1007/BF00543973.
10
Morphine intoxication in renal failure: the role of morphine-6-glucuronide.肾衰竭中的吗啡中毒：吗啡-6-葡萄糖醛酸的作用
Br Med J (Clin Res Ed). 1986 Jun 14;292(6535):1548-9. doi: 10.1136/bmj.292.6535.1548.

吗啡-6-葡萄糖醛酸诱导的长期呼吸抑制？

Long lasting respiratory depression induced by morphine-6-glucuronide?

作者信息

Hasselström J, Berg U, Löfgren A, Säwe J

机构信息

Department of Clinical Pharmacology, Huddinge Hospital, Karolinska Institute, Sweden.

出版信息

Br J Clin Pharmacol. 1989 Apr;27(4):515-8. doi: 10.1111/j.1365-2125.1989.tb05401.x.

DOI:10.1111/j.1365-2125.1989.tb05401.x
PMID:2719905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1379732/
Abstract

We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome. The plasma concentrations of the active metabolite M6G were more than 10 times those normally seen and the half-lives of M6G and morphine were prolonged.

摘要

我们报告了一例7岁溶血尿毒综合征女童静脉注射吗啡后出现长期呼吸抑制的病例。活性代谢物M6G的血浆浓度比正常情况高出10倍以上，且M6G和吗啡的半衰期延长。