o-氨基苯甲酰胺与甲醇的无受体脱氢偶联反应及构建喹唑啉酮的 C1 源的应用。
Acceptorless Dehydrogenative Coupling of o-Aminobenzamides with the Activation of Methanol as a C1 Source for the Construction of Quinazolinones.
机构信息
School of Chemical Engineering, Nanjing University of Science & Technology , Nanjing 210094, China.
State Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian 116024, China.
出版信息
Org Lett. 2016 Jun 3;18(11):2580-3. doi: 10.1021/acs.orglett.6b00925. Epub 2016 May 23.
A strategy for the synthesis of quinazolinones via acceptorless coupling of o-aminobenzamides with methanol has been accomplished in the presence of the metal-ligand bifunctional catalyst [Cp*Ir(2,2'-bpyO)(H2O)]. Notably, this research exhibited the potential of transition-metal-catalyzed activation of methanol as a C1 source for the construction of heterocycles.
在金属-配体双功能催化剂 [Cp*Ir(2,2'-bpyO)(H2O)] 的存在下，实现了通过邻氨基苯甲酰胺与甲醇的无受体偶联来合成喹唑啉酮的策略。值得注意的是，这项研究展示了过渡金属催化甲醇作为 C1 源用于构建杂环的潜力。
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