Joffe Yael T, Houghton Christine A
Manuka Science, 17 Roeland Square, Drury Lane, Cape Town, South Africa.
Department of Nutritional Sciences, School of Health Related Professions, Rutgers School of Dental Medicine, Newark, NJ, USA.
Curr Oncol Rep. 2016 Jul;18(7):43. doi: 10.1007/s11912-016-0529-6.
Nutrigenetics and nutrigenomics, as well as diet and exercise, play an important role in the development and treatment of obesity and its comorbidities. If an individual's susceptibility to becoming obese and their responsiveness to weight loss interventions are to be understood, then it needs to be addressed at a molecular and metabolic level, including genetic interaction. This review proposes a three-pillar approach to more fully comprehend the complexity of diet-gene interactions in obesity. Peroxisomal proliferating-activated receptor gamma (PPARG) and mitochondrial uncoupling protein-1 (UCP-1) are explored in detail. Illustrating how an understanding of nutritional biochemistry, nutrigenomics, and nutrigenetics may be the key to understanding differences observed in the obese phenotype that vary both within and across populations.
营养遗传学、营养基因组学以及饮食与运动，在肥胖症及其合并症的发生发展和治疗过程中发挥着重要作用。若要了解个体肥胖易感性以及其对减肥干预措施的反应，就需要在分子和代谢层面进行探讨，其中包括基因相互作用。本综述提出了一种三支柱方法，以更全面地理解肥胖症中饮食与基因相互作用的复杂性。对过氧化物酶体增殖物激活受体γ（PPARG）和线粒体解偶联蛋白-1（UCP-1）进行了详细探讨。阐明了理解营养生物化学、营养基因组学和营养遗传学如何可能是理解在肥胖表型中观察到的、在不同人群内部和不同人群之间存在差异的关键。
