Bertazzi P A, Pesatori A C, Zocchetti C, Latocca R
Institute of Occupational Health, Clinica L. Devoto, Università degli Studi di Milano, Italy.
Int Arch Occup Environ Health. 1989;61(4):261-70. doi: 10.1007/BF00381424.
The mortality experience of 1595 male workers employed in one of the largest Italian refineries in the period from 1949-1982 was examined. From the comparison with national and local death rates, increases in mortality owing to lung and kidney cancers, brain tumors, and leukemias emerged. No definite trends according to duration of exposure and years since first exposure were apparent. The increases regarding cancer of the lung, kidney and brain appeared to be associated with the early period of operations. Analysis by exposure category suggested an association of the increased mortality from leukemias with working in production (observed = 2; expected = 0.61). Kidney cancer mortality was elevated among maintenance workers (obs. = 2; exp. = 0.18). Small numbers prevented firmer conclusions. Workers in the moving department had a significantly increased mortality from all cancers (obs. = 22; exp. = 11.7), and lung cancer (obs. = 11; exp. = 3.6). Confounding by smoking could be excluded as sufficient explanation of the three-fold increase in lung cancer deaths. It was in moving that highest airborne levels of polynuclear aromatic hydrocarbons had been discovered in an independent environmental investigation.
对1949年至1982年期间受雇于意大利最大炼油厂之一的1595名男性工人的死亡情况进行了调查。通过与国家和地方死亡率的比较，发现肺癌、肾癌、脑肿瘤和白血病导致的死亡率有所上升。根据接触时间和首次接触后的年份，未发现明显的明确趋势。肺癌、肾癌和脑癌的增加似乎与早期运营有关。按接触类别分析表明，白血病死亡率的增加与生产工作有关（观察值=2；期望值=0.61）。维修工人的肾癌死亡率有所升高（观察值=2；期望值=0.18）。由于数量较少，无法得出更确凿的结论。运输部门的工人所有癌症的死亡率显著增加（观察值=22；期望值=11.7），肺癌死亡率（观察值=11；期望值=3.6）。吸烟造成的混杂因素不能充分解释肺癌死亡人数增加三倍的情况。在一次独立的环境调查中，正是在运输部门发现了空气中多环芳烃的最高含量。
