Latifi Shahrzad, Tamayol Ali, Habibey Rouhollah, Sabzevari Reza, Kahn Cyril, Geny David, Eftekharpour Eftekhar, Annabi Nasim, Blau Axel, Linder Michel, Arab-Tehrany Elmira
Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy.
Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Sci Rep. 2016 May 27;6:25777. doi: 10.1038/srep25777.
Phospholipids in the brain cell membranes contain different polyunsaturated fatty acids (PUFAs), which are critical to nervous system function and structure. In particular, brain function critically depends on the uptake of the so-called "essential" fatty acids such as omega-3 (n-3) and omega-6 (n-6) PUFAs that cannot be readily synthesized by the human body. We extracted natural lecithin rich in various PUFAs from a marine source and transformed it into nanoliposomes. These nanoliposomes increased neurite outgrowth, network complexity and neural activity of cortical rat neurons in vitro. We also observed an upregulation of synapsin I (SYN1), which supports the positive role of lecithin in synaptogenesis, synaptic development and maturation. These findings suggest that lecithin nanoliposomes enhance neuronal development, which may have an impact on devising new lecithin delivery strategies for therapeutic applications.
脑细胞膜中的磷脂含有不同的多不饱和脂肪酸（PUFAs），这些脂肪酸对神经系统的功能和结构至关重要。特别是，大脑功能严重依赖于摄取所谓的“必需”脂肪酸，如ω-3（n-3）和ω-6（n-6）多不饱和脂肪酸，而人体无法轻易合成这些脂肪酸。我们从海洋来源提取了富含各种多不饱和脂肪酸的天然卵磷脂，并将其转化为纳米脂质体。这些纳米脂质体在体外增加了大鼠皮层神经元的神经突生长、网络复杂性和神经活动。我们还观察到突触素I（SYN1）的上调，这支持了卵磷脂在突触形成、突触发育和成熟中的积极作用。这些发现表明，卵磷脂纳米脂质体可促进神经元发育，这可能对设计用于治疗应用的新的卵磷脂递送策略产生影响。
