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Nat Genet. 2015 Jun;47(6):569-76. doi: 10.1038/ng.3259. Epub 2015 Apr 27.
2
Differences in DNA methylation profile of Th1 and Th2 cytokine genes are associated with tolerance acquisition in children with IgE-mediated cow's milk allergy.辅助性T细胞1（Th1）和辅助性T细胞2（Th2）细胞因子基因的DNA甲基化谱差异与IgE介导的牛奶过敏儿童的耐受获得有关。
Clin Epigenetics. 2015 Mar 31;7(1):38. doi: 10.1186/s13148-015-0070-8. eCollection 2015.
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An epigenome-wide association study of total serum immunoglobulin E concentration.一项关于血清总免疫球蛋白E浓度的全表观基因组关联研究。
Nature. 2015 Apr 30;520(7549):670-674. doi: 10.1038/nature14125. Epub 2015 Feb 18.
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Blood DNA methylation biomarkers predict clinical reactivity in food-sensitized infants.血液 DNA 甲基化生物标志物可预测食物致敏婴儿的临床反应性。
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Early life precursors, epigenetics, and the development of food allergy.早期生活前体、表观遗传学与食物过敏的发生发展。
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全基因组关联研究将特定部位的 DNA 甲基化变化与牛奶过敏联系起来。

Epigenome-wide association study links site-specific DNA methylation changes with cow's milk allergy.

机构信息

Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.

Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.

出版信息

J Allergy Clin Immunol. 2016 Sep;138(3):908-911.e9. doi: 10.1016/j.jaci.2016.01.056. Epub 2016 Apr 25.

DOI:10.1016/j.jaci.2016.01.056
PMID:27236499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5392112/
Abstract

We demonstrates that DNA methylation alterations at multiple genes, including those in the TH-TH pathways and some novel genes, are associated with cow's milk allergy (CMA), which shed new light on the epigenetic underpinnings of CMA.

摘要

我们证明了多个基因的 DNA 甲基化改变与牛奶过敏（CMA）有关，包括 TH-TH 途径中的基因和一些新基因，这为 CMA 的表观遗传基础提供了新的线索。