Yu Ru-Jian, Liu Hai-Bin, Yu Yang, Liang Lu, Xu Rui, Liang Chun, Tang Jin-Shan, Yao Xin-Sheng
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Division of Life Science, Center for Cancer Research, State Key Lab for Molecular Neural Science, Bioengineering Graduate Program, Hong Kong University of Science and Technology, Hong Kong, PR China; Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd, Guangzhou, PR China.
Fitoterapia. 2016 Jul;112:175-82. doi: 10.1016/j.fitote.2016.05.015. Epub 2016 May 27.
Phytochemical investigation of the stem of Urceola huaitingii resulted in the isolation of nine proanthocyanidins (1-9), including a new compound (9). Their chemical structures were determined by UV, (HR) ESI-MS, 1D-, 2D-NMR, and CD spectra in combination with chemical derivatization. Determination of the absolute configuration of proanthocyanidins were discussed, which suggested that positive Δε values at 245nm can be applied to determine the absolute configuration of them. In addition, anticancer activities of proanthocyanidins (1-9) and their synergistic anticancer effects in combination with chemotherapeutics were evaluated. The results showed that some proanthocyanidins, especially compound 7 possessing two doubly interflavonoid linkages, exhibited significant synergistic anticancer effects with some chemotherapeutics in multiple cancer cell lines.
对怀廷腰骨藤茎进行植物化学研究，从中分离出9种原花青素（1 - 9），包括一种新化合物（9）。通过紫外光谱、（高分辨）电喷雾电离质谱、一维和二维核磁共振光谱以及圆二色光谱并结合化学衍生化确定了它们的化学结构。讨论了原花青素绝对构型的测定方法，结果表明在245nm处的正Δε值可用于确定其绝对构型。此外，还评估了原花青素（1 - 9）的抗癌活性及其与化疗药物联合使用时的协同抗癌效果。结果表明，一些原花青素，尤其是具有两个双黄酮间键的化合物7，在多种癌细胞系中与某些化疗药物表现出显著的协同抗癌作用。
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