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疟疾:2000-2015 年全球进展及未来挑战。

Malaria: Global progress 2000 - 2015 and future challenges.

机构信息

Global Malaria Programme, World Health Organization, 20 avenue Appia, 1211, Geneva 27, Switzerland.

出版信息

Infect Dis Poverty. 2016 Jun 9;5(1):61. doi: 10.1186/s40249-016-0151-8.

Abstract

BACKGROUND

2015 was the target year for malaria goals set by the World Health Assembly and other international institutions to reduce malaria incidence and mortality. A review of progress indicates that malaria programme financing and coverage have been transformed since the beginning of the millennium, and have contributed to substantial reductions in the burden of disease.

FINDINGS

Investments in malaria programmes increased by more than 2.5 times between 2005 and 2014 from US$ 960 million to US$ 2.5 billion, allowing an expansion in malaria prevention, diagnostic testing and treatment programmes. In 2015 more than half of the population of sub-Saharan Africa slept under insecticide-treated mosquito nets, compared to just 2 % in 2000. Increased availability of rapid diagnostic tests and antimalarial medicines has allowed many more people to access timely and appropriate treatment. Malaria incidence rates have decreased by 37 % globally and mortality rates by 60 % since 2000. It is estimated that 70 % of the reductions in numbers of cases in sub-Saharan Africa can be attributed to malaria interventions.

CONCLUSIONS

Reductions in malaria incidence and mortality rates have been made in every WHO region and almost every country. However, decreases in malaria case incidence and mortality rates were slowest in countries that had the largest numbers of malaria cases and deaths in 2000; reductions in incidence need to be greatly accelerated in these countries to achieve future malaria targets. Progress is made challenging because malaria is concentrated in countries and areas with the least resourced health systems and the least ability to pay for system improvements. Malaria interventions are nevertheless highly cost-effective and have not only led to significant reductions in the incidence of the disease but are estimated to have saved about US$ 900 million in malaria case management costs to public providers in sub-Saharan Africa between 2000 and 2014. Investments in malaria programmes can not only reduce malaria morbidity and mortality, thereby contributing to the health targets of the Sustainable Development Goals, but they can also transform the well-being and livelihood of some of the poorest communities across the globe.

摘要

背景

2015 年是世界卫生大会和其他国际机构设定的疟疾目标年,旨在降低疟疾发病率和死亡率。对进展情况的审查表明,自千年之交以来,疟疾规划的供资和覆盖范围发生了转变,并为疾病负担的大幅减轻做出了贡献。

发现

2005 年至 2014 年,疟疾规划投资增加了 2.5 倍以上,从 9.6 亿美元增至 25 亿美元,从而扩大了疟疾预防、诊断检测和治疗方案。2015 年,撒哈拉以南非洲地区超过一半的人口使用了经杀虫剂处理的蚊帐,而 2000 年这一比例仅为 2%。快速诊断检测和抗疟药物的供应增加,使更多的人能够及时获得适当的治疗。自 2000 年以来,全球疟疾发病率下降了 37%,死亡率下降了 60%。据估计,撒哈拉以南非洲地区病例减少的 70%可归因于疟疾干预措施。

结论

世卫组织所有区域和几乎所有国家的疟疾发病率和死亡率都有所下降。然而,在 2000 年疟疾病例和死亡人数最多的国家,疟疾发病率和死亡率的下降速度最慢;这些国家需要大大加快发病率的下降速度,以实现未来的疟疾目标。进展之所以具有挑战性,是因为疟疾集中在资源最匮乏的卫生系统和最无力支付系统改善费用的国家和地区。然而,疟疾干预措施具有很高的成本效益,不仅显著降低了疾病的发病率,而且据估计,在 2000 年至 2014 年期间,撒哈拉以南非洲的公共提供者在疟疾病例管理方面节省了约 9 亿美元的费用。对疟疾规划的投资不仅可以降低疟疾发病率和死亡率,从而有助于实现可持续发展目标的健康目标,还可以改变全球一些最贫困社区的福祉和生计。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c4/4901420/0391af4c7b2e/40249_2016_151_Fig1_HTML.jpg

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