Xu Fang, Zhang Hua, Qi Hongbo
Department of Emergency, The First Affiliated Hospital of Chongqing Medical University, China.
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, China.
J Renin Angiotensin Aldosterone Syst. 2016 Jun 12;17(2):1470320316653283. doi: 10.1177/1470320316653283. Print 2016 Apr-Jun.
Adiponectin (ADIPOQ), involved in regulating glucose levels and fatty acid oxidation, plays key roles in metabolic derangements such as gestational diabetes mellitus (GDM). Previously, several studies have been conducted to assess the association between ADIPOQ +45 T/G polymorphism and risk of GDM. The results, however, are inconclusive. We aimed to evaluate the effect of the polymorphism on the risk of GDM using a meta-analysis.
After databases searching, eight records were identified. Pooled odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were used to evaluate the association between ADIPOQ +45 T/G polymorphism and risk of GDM.
No significant association was observed between the ADIPOQ +45 T/G polymorphism and the risk of GDM (heterozygote comparison: OR = 1.15, 95% CI, 0.70-1.89; homozygote comparison: OR = 1.21, 95% CI, 0.48-3.03; dominant model: OR = 0.86, 95% CI, 0.50-1.48, recessive model: OR = 1.21, 95% CI, 0.62-2.33, and allele comparison: OR = 1.17, 95% CI, 0.79-1.76, respectively). Apparent heterogeneity was detected. However, no evidence of publication bias was found.
This meta-analysis provides evidence that the ADIPOQ +45 T/G polymorphism was not related to the risk of GDM. Further multicenter, prospective studies with larger sample size would be valuable to confirm the result.
脂联素（ADIPOQ）参与调节血糖水平和脂肪酸氧化，在诸如妊娠期糖尿病（GDM）等代谢紊乱中起关键作用。此前，已有多项研究评估ADIPOQ +45 T/G多态性与GDM风险之间的关联。然而，结果尚无定论。我们旨在通过荟萃分析评估该多态性对GDM风险的影响。
在检索数据库后，共识别出8条记录。采用合并比值比（OR）及其相应的95%置信区间（CI）来评估ADIPOQ +45 T/G多态性与GDM风险之间的关联。
未观察到ADIPOQ +45 T/G多态性与GDM风险之间存在显著关联（杂合子比较：OR = 1.15，95% CI，0.70 - 1.89；纯合子比较：OR = 1.21，95% CI，0.48 - 3.03；显性模型：OR = 0.86，95% CI，0.50 - 1.48，隐性模型：OR = 1.21，95% CI，0.62 - 2.33，等位基因比较：OR = 1.17，95% CI，0.79 - 1.76）。检测到明显的异质性。然而，未发现发表偏倚的证据。
该荟萃分析提供的证据表明，ADIPOQ +45 T/G多态性与GDM风险无关。进一步开展更大样本量的多中心前瞻性研究对于证实该结果将具有重要价值。
