Host Kurtis M, Damania Blossom
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
mSphere. 2016 Feb 17;1(1). doi: 10.1128/mSphere.00016-16. eCollection 2016 Jan-Feb.
Zoonosis is the leading cause of emerging infectious diseases. In a recent article, R. S. Shabman et al. (mSphere 1[1]:e00070-15, 2016, http://dx.doi.org/10.1128/mSphere.00070-15) report the identification of a novel gammaherpesvirus in a cell line derived from the microbat Myotis velifer incautus. This is the first report on a replicating, infectious gammaherpesvirus from bats. The new virus is named bat gammaherpesvirus 8 (BGHV8), also known as Myotis gammaherpesvirus 8, and is able to infect multiple cell lines, including those of human origin. Using next-generation sequencing technology, the authors constructed a full-length annotated genomic map of BGHV8. Phylogenetic analysis of several genes from BGHV8 revealed similarity to several mammalian gammaherpesviruses, including Kaposi's sarcoma-associated herpesvirus (KSHV).
人畜共患病是新发传染病的主要病因。在最近一篇文章中，R. S. 沙布曼等人（《mSphere》1[1]:e00070 - 15, 2016, http://dx.doi.org/10.1128/mSphere.00070 - 15）报告了在源自墨西哥无尾蝠（Myotis velifer incautus）的细胞系中鉴定出一种新型γ疱疹病毒。这是关于来自蝙蝠的可复制、具传染性的γ疱疹病毒的首次报告。这种新病毒被命名为蝙蝠γ疱疹病毒8（BGHV8），也称为无尾蝠γ疱疹病毒8，并且能够感染多种细胞系，包括人源细胞系。作者利用新一代测序技术构建了BGHV8的全长注释基因组图谱。对BGHV8的几个基因进行系统发育分析发现，它与几种哺乳动物γ疱疹病毒相似，包括卡波西肉瘤相关疱疹病毒（KSHV）。
