Wheelton Andrew, Mace James, Khan Wasim S, Anand Sanjay
University College London Institute of Orthopaedics and Musculoskeletal Science, Royal National Orthopaedic Hospital, Stanmore, London, HA7 4LP, UK.
Curr Stem Cell Res Ther. 2016;11(7):578-84.
Tissue engineering has emerged as a promising scientific field potentially yielding in vitro developed tissue to replace degenerative or injured tissues in vivo, thus avoiding the donor site morbidity associated with reconstructive surgery. Integral to the process is the role of scaffolds and the biomaterials used to form them. This review explores the concept of scaffold based tissue engineering and design considerations. The scaffold needs to have certain mechanical and architectural properties, it needs to be biocompatible and biodegradable, and allow combination with bioactive molecules. We also discuss scaffolding techniques, different biomaterial options and fabrication technologies, and future areas of development.
组织工程已成为一个充满前景的科学领域，有望在体外培育出组织以替代体内退化或受损的组织，从而避免与重建手术相关的供体部位并发症。该过程的核心是支架以及用于构建支架的生物材料所起的作用。本综述探讨了基于支架的组织工程概念及设计考量。支架需要具备一定的机械和结构特性，需具有生物相容性和可生物降解性，并允许与生物活性分子结合。我们还讨论了支架技术、不同的生物材料选择和制造技术，以及未来的发展领域。
