Kuttappan Shruthy, Mathew Dennis, Nair Manitha B
Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences & Research Center, Amrita Vishwa Vidyapeetham University, Kochi, 682041 Kerala, India.
Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences & Research Center, Amrita Vishwa Vidyapeetham University, Kochi, 682041 Kerala, India.
Int J Biol Macromol. 2016 Dec;93(Pt B):1390-1401. doi: 10.1016/j.ijbiomac.2016.06.043. Epub 2016 Jun 15.
Bone is a natural composite material consisting of an organic phase (collagen) and a mineral phase (calcium phosphate, especially hydroxyapatite). The strength of bone is attributed to the apatite, while the collagen fibrils are responsible for the toughness and visco-elasticity. The challenge in bone tissue engineering is to develop such biomimetic composite scaffolds, having a balance between biological and biomechanical properties. This review summarizes the current state of the field by outlining composite scaffolds made of gelatin/collagen in combination with bioactive ceramics for bone tissue engineering application.
骨是一种天然复合材料，由有机相（胶原蛋白）和无机相（磷酸钙，尤其是羟基磷灰石）组成。骨的强度归因于磷灰石，而胶原纤维则赋予骨韧性和粘弹性。骨组织工程面临的挑战是开发出具有生物性能和生物力学性能平衡的仿生复合支架。本文综述概述了用于骨组织工程的由明胶/胶原蛋白与生物活性陶瓷组成的复合支架，总结了该领域的现状。
