Archer S L, Johnson G J, Gebhard R L, Castleman W L, Levine A S, Westcott J Y, Voelkel N F, Nelson D P, Weir E K
Minneapolis Veterans Administration Medical Center, Department of Medicine, Minnesota.
J Appl Physiol (1985). 1989 Apr;66(4):1662-73. doi: 10.1152/jappl.1989.66.4.1662.
The effects of dietary polyunsaturated fats on chronic hypoxic pulmonary hypertension were assessed in rats fed fish oil, corn oil, or a lower fat, "high-carbohydrate" diet (regular) beginning 1 mo before the start of hypoxia (0.4 atm, n = 30 for each). Mean pulmonary arterial pressures were lower in the chronically hypoxic rats fed fish oil (19.7 +/- 1.8 mm Hg) than in the rats fed corn oil (25.3 +/- 1.6 mm Hg) or regular diets (27.5 +/- 1.5 mm Hg, P less than 0.05). The fish oil diet increased lung eicosapentaenoic acid 50-fold and depleted lung arachidonic acid 60% (P less than 0.0001 for each). Lung thromboxane B2 and 6-ketoprostaglandin F1 alpha levels were lower, and platelet aggregation, in response to collagen, was reduced in rats fed fish oil. Chronically hypoxic rats fed fish oil had lower mortality rates than the other hypoxic rats. They also had lower blood viscosity, as well as less right ventricular hypertrophy and less peripheral extension of vascular smooth muscle to intra-acinar pulmonary arteries (P less than 0.05 for each). The mechanism by which dietary fish oil decreases pulmonary hypertension and vascular remodeling during chronic hypoxia remains uncertain. The finding that a fish oil diet can reduce the hemodynamic and morphological sequelae of chronic hypoxia may have therapeutic significance.
在缺氧开始前1个月起，给大鼠喂食鱼油、玉米油或低脂“高碳水化合物”饮食（常规饮食），以评估膳食多不饱和脂肪对慢性低氧性肺动脉高压的影响（0.4个大气压，每组n = 30）。长期低氧的大鼠中，喂食鱼油的大鼠平均肺动脉压（19.7±1.8毫米汞柱）低于喂食玉米油的大鼠（25.3±1.6毫米汞柱）或常规饮食的大鼠（27.5±1.5毫米汞柱，P<0.05）。鱼油饮食使肺二十碳五烯酸增加50倍，并使肺花生四烯酸减少60%（每项P<0.0001）。喂食鱼油的大鼠肺血栓素B2和6-酮前列腺素F1α水平较低，对胶原蛋白的血小板聚集反应降低。喂食鱼油的长期低氧大鼠死亡率低于其他低氧大鼠。它们还具有较低的血液粘度，以及较少的右心室肥厚和血管平滑肌向腺泡内肺动脉的外周延伸（每项P<0.05）。膳食鱼油在慢性缺氧期间降低肺动脉高压和血管重塑的机制尚不确定。鱼油饮食可减轻慢性缺氧的血流动力学和形态学后遗症这一发现可能具有治疗意义。
