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1
Drug-nucleic acid interactions: conformational flexibility at the intercalation site.药物 - 核酸相互作用：嵌入位点的构象灵活性。
Proc Natl Acad Sci U S A. 1978 Feb;75(2):828-32. doi: 10.1073/pnas.75.2.828.
2
Visualization of planar drug intercalations in B-DNA.B型DNA中平面药物插入的可视化。
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4
Nucleic acid model building: the multiple backbone solutions associated with a given base morphology.核酸模型构建：与特定碱基形态相关的多种主链解决方案。
J Biomol Struct Dyn. 1987 Jun;4(6):895-938. doi: 10.1080/07391102.1987.10507690.
5
The influence of helix morphology on co-operative polyamide backbone conformational flexibility in peptide nucleic acid complexes.螺旋形态对肽核酸复合物中协同聚酰胺主链构象灵活性的影响。
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6
Base pairing in 5-chlorouridine.5-氯尿苷中的碱基配对。
Proc Natl Acad Sci U S A. 1969 Aug;63(4):1359-64. doi: 10.1073/pnas.63.4.1359.
7
Visualization of drug-nucleic acid interactions at atomic resolution. VII. Structure of an ethidium/dinucleoside monophosphate crystalline complex, ethidium: uridylyl(3'-5') adenosine.药物与核酸相互作用的原子分辨率可视化。VII. 溴化乙锭/二核苷单磷酸晶体复合物的结构，溴化乙锭：尿苷酰基（3'-5'）腺苷。
J Biomol Struct Dyn. 1984 Mar;1(5):1161-77. doi: 10.1080/07391102.1984.10507510.
8
Conformation-dependent restraints for polynucleotides: the sugar moiety.构象相关约束在多核苷酸中的应用：糖部分。
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Solution conformation of the (-)-trans-anti-[BP]dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo[a]pyrene into the helix with base displacement of the modified deoxyguanosine into the minor groove.DNA双链中与缺失位点相对的（-）-反式-反-[BP]dG加合物的溶液构象：共价连接的苯并[a]芘嵌入螺旋，修饰的脱氧鸟苷碱基位移至小沟。
Biochemistry. 1997 Nov 11;36(45):13780-90. doi: 10.1021/bi970070r.

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Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3050-5. doi: 10.1073/pnas.1317799111. Epub 2014 Feb 10.
2
Synthesis and structural characterization of piperazino-modified DNA that favours hybridization towards DNA over RNA.哌嗪基修饰的 DNA 的合成及结构表征，该修饰的 DNA 有利于与 DNA 杂交而不是与 RNA 杂交。
Nucleic Acids Res. 2011 Mar;39(5):1953-65. doi: 10.1093/nar/gkq1123. Epub 2010 Nov 9.
3
Crystal structure of an RNA.DNA hybrid reveals intermolecular intercalation: dimer formation by base-pair swapping.RNA-DNA杂交体的晶体结构揭示了分子间嵌入：通过碱基对交换形成二聚体。
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9214-9. doi: 10.1073/pnas.1533326100. Epub 2003 Jul 18.
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6
Molecular mechanical studies of proflavine and acridine orange intercalation.硫酸原黄素和吖啶橙嵌入的分子力学研究。
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7
Correlation between glycosyl torsion angle and sugar ring pucker does not always exist.糖基扭转角与糖环构象之间并不总是存在相关性。
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8
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9
X-ray-structure of a cytidylyl-3',5'-adenosine-proflavine complex: a self-paired parallel-chain double helical dimer with an intercalated acridine dye.胞苷酰-3',5'-腺苷-硫酸普罗黄素复合物的X射线结构：一种带有嵌入吖啶染料的自配对平行链双螺旋二聚体。
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10
Conformational characteristics of dimeric subunits of RNA from energy minimization studies. Mixed sugar-puckered ApG, ApU, CpG, and CpU.来自能量最小化研究的RNA二聚体亚基的构象特征。混合糖型的ApG、ApU、CpG和CpU。
Biophys J. 1981 Sep;35(3):753-69. doi: 10.1016/S0006-3495(81)84825-4.

本文引用的文献

1
Structural considerations in the interaction of DNA and acridines.DNA与吖啶相互作用中的结构考量
J Mol Biol. 1961 Feb;3:18-30. doi: 10.1016/s0022-2836(61)80004-1.
2
The crystal structures of purines, pyrimidines and their intermolecular complexes.嘌呤、嘧啶及其分子间复合物的晶体结构。
Prog Nucleic Acid Res Mol Biol. 1970;10:183-265. doi: 10.1016/s0079-6603(08)60565-6.
3
Visualization of planar drug intercalations in B-DNA.B型DNA中平面药物插入的可视化。
Nucleic Acids Res. 1975 Oct;2(10):1701-17. doi: 10.1093/nar/2.10.1701.
4
X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA.铂金属嵌入试剂与DNA邻位排斥结合的X射线纤维衍射证据。
Proc Natl Acad Sci U S A. 1975 Dec;72(12):4825-9. doi: 10.1073/pnas.72.12.4825.
5
X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine.药物与核酸插入结合的X射线晶体学可视化：溴化乙锭-二核苷单磷酸晶体复合物的结构，溴化乙锭：5-碘尿苷酰基（3'-5'）腺苷。
Proc Natl Acad Sci U S A. 1975 Feb;72(2):628-32. doi: 10.1073/pnas.72.2.628.
6
RNA double-helical fragments at atomic resolution. II. The crystal structure of sodium guanylyl-3',5'-cytidine nonahydrate.原子分辨率下的RNA双螺旋片段。II. 鸟苷酰-3',5'-胞苷九水合钠的晶体结构。
J Mol Biol. 1976 Jun 14;104(1):145-67. doi: 10.1016/0022-2836(76)90006-1.
7
RNA double-helical fragments at atomic resolution. I. The crystal and molecular structure of sodium adenylyl-3',5'-uridine hexahydrate.原子分辨率下的RNA双螺旋片段。I. 腺苷酰-3',5'-尿苷六水合钠的晶体和分子结构。
J Mol Biol. 1976 Jun 14;104(1):109-44. doi: 10.1016/0022-2836(76)90005-x.
8
Visualization of drug-nucleic acid interactions at atomic resolution. II. Structure of an ethidium/dinucleoside monophosphate crystalline complex, ethidium:5-iodocytidylyl (3'-5') guanosine.药物与核酸相互作用的原子分辨率可视化。II. 溴化乙锭/二核苷单磷酸晶体复合物的结构，溴化乙锭：5-碘胞苷酰基（3'-5'）鸟苷。
J Mol Biol. 1977 Aug 15;114(3):317-31. doi: 10.1016/0022-2836(77)90253-4.
9
Visualization of drug-nucleic acid interactions at atomic resolution. I. Structure of an ethidium/dinucleoside monophosphate crystalline complex, ethidium:5-iodouridylyl (3'-5') adenosine.药物与核酸相互作用的原子分辨率可视化。I. 溴化乙锭/二核苷单磷酸晶体复合物的结构，溴化乙锭：5-碘尿苷酰基（3'-5'）腺苷。
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10
Structure of a dinucleoside phosphate--drug complex as model for nucleic acid--drug interaction.磷酸二核苷-药物复合物的结构作为核酸-药物相互作用的模型
Nature. 1977 Sep 22;269(5626):304-7. doi: 10.1038/269304a0.

药物 - 核酸相互作用：嵌入位点的构象灵活性。

Drug-nucleic acid interactions: conformational flexibility at the intercalation site.

作者信息

Berman H M, Neidle S, Stodola R K

出版信息

Proc Natl Acad Sci U S A. 1978 Feb;75(2):828-32. doi: 10.1073/pnas.75.2.828.

DOI:10.1073/pnas.75.2.828
PMID:273246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC411350/
Abstract

The conformational features of the intercalation site in polynucleotides were examined. We found that, for all the crystal structures of drug-dinucleoside complexes studied thus far, two torsion angles differ from those found in A RNA (phi and chi) and that alternate sugar puckering is not a prerequisite for intercalation. This intercalation geometry, which is the basis of helix axis displacement in a polymer, would necessitate conformational changes in the adjacent nucleotides. The base-turn angle is less sensitive to the conformation of the backbone than it is to small alterations in the base-pairing geometry. We postulate that this angle is dependent on the nature of the intercalating drug.

摘要

对多核苷酸中嵌入位点的构象特征进行了研究。我们发现，就目前所研究的药物 - 二核苷复合物的所有晶体结构而言，有两个扭转角与A RNA中的扭转角（φ和χ）不同，并且交替的糖折叠不是嵌入的先决条件。这种嵌入几何结构是聚合物中螺旋轴位移的基础，它将使相邻核苷酸发生构象变化。碱基转角对主链构象的敏感性低于对碱基配对几何结构微小变化的敏感性。我们推测这个角度取决于嵌入药物的性质。