Buzzo K, Fouts D L, Wolstenholme D R
Proc Natl Acad Sci U S A. 1978 Feb;75(2):909-13. doi: 10.1073/pnas.75.2.909.
The mitochondrial DNA (mtDNA) molecules of some rats obtained from the SASCO colony contain six EcoRI-sensitive sites while the mtDNA molecules of other rats obtained from the same source contain only four EcoRI sites. By mapping the positions of the EcoRI sites on the molecules relative to the D-loop it was determined that mtDNA molecules from all rats have four EcoRI sites in common, but all the mtDNA molecules of some rats have two extra EcoRI sites. EcoRI sensitivity of mtDNA molecules was shown to be maternally inherited. Construction of heteroduplex molecules failed to reveal evidence of gross nucleotide sequence changes associated with differences in EcoRI sensitivity.
从SASCO种群获得的一些大鼠的线粒体DNA（mtDNA）分子含有六个EcoRI敏感位点，而从同一来源获得的其他大鼠的mtDNA分子仅含有四个EcoRI位点。通过绘制分子上EcoRI位点相对于D环的位置，确定所有大鼠的mtDNA分子共有四个EcoRI位点，但一些大鼠的所有mtDNA分子都有两个额外的EcoRI位点。mtDNA分子的EcoRI敏感性显示为母系遗传。异源双链分子的构建未能揭示与EcoRI敏感性差异相关的总体核苷酸序列变化的证据。
