Seemann Rainer, Filippi Andreas, Michaelis Sebastian, Lauterbach Susanne, John Hans-Dieter, Huismann Jörg
Department of Preventive-, Restorative- and Pediatric Dentistry, zmk bern, University Bern, Freiburgstrasse 7, CH-3010 Bern, Switzerland. www.zmk.unibe.ch.
J Breath Res. 2016 Jun 22;10(3):036002. doi: 10.1088/1752-7155/10/3/036002.
Halitosis occurs in approximately 30% of the adult population and has a negative social and psychological impact on affected individuals. Mouthwashes may be used to prevent unpleasant odour, with long-duration of effect being a desirable attribute. The aim of this study was to assess the long-term efficacy of CB12 (a mixture of 0.3% zinc acetate and 0.025% chlorhexidine) for the treatment of intra-oral halitosis. Thirty-four subjects with confirmed intra-oral halitosis were randomized into a double-blind, controlled, cross-over study to one of 2 groups; (i) CB12-water-water or (ii) water-CB12-CB12. Each group comprised 3 treatments, each given evening and morning (12 h apart) on consecutive study days, with a 5 d washout between treatments. Intra-oral halitosis was assessed objectively by measuring concentrations of hydrogen sulphide, methyl mercaptan, dimethyl sulphide and total volatile sulphur compound (VSC) concentrations and subjectively using organoleptic score (OLS). These were measured at baseline, 12 h after the evening rinse (i.e. 12 h overnight assessment) and 12 h after the daytime rinse (i.e. 12 h day time assessment). CB12 significantly reduced mean hydrogen sulphide, methyl mercaptan, dimethyl sulphide and VSC concentrations, with a duration of effect lasting 12 h, whether assessed overnight (all p ⩽ 0.0003 versus water) or during the day (all p ⩽ 0.0007 versus water). CB12's effect on OLS was also evident for 12 h overnight (p = 0.0043). CB12 was well-tolerated. In conclusion, CB12 showed a clear and durable effect on intra-oral halitosis which lasted at least 12 h, both during the day and overnight, with consistent effect on both objective and subjective variables.
约30%的成年人口患有口臭，这对受影响个体产生负面的社会和心理影响。漱口水可用于预防口气不佳，长效是其理想特性。本研究的目的是评估CB12（0.3%醋酸锌和0.025%氯己定的混合物）治疗口腔内口臭的长期疗效。34名确诊口腔内口臭的受试者被随机分为双盲、对照、交叉研究的2组之一：（i）CB12-水-水组或（ii）水-CB12-CB12组。每组包括3种治疗，在连续的研究日中每天早晚（间隔12小时）各进行一次，治疗之间有5天的洗脱期。通过测量硫化氢、甲硫醇、二甲基硫醚和总挥发性硫化物（VSC）浓度客观评估口腔内口臭，并使用感官评分（OLS）进行主观评估。在基线、晚上漱口后12小时（即12小时夜间评估）和白天漱口后12小时（即12小时日间评估）进行测量。CB12显著降低了硫化氢、甲硫醇、二甲基硫醚和VSC的平均浓度，无论夜间（与水相比，所有p⩽0.0003）还是白天（与水相比，所有p⩽0.0007）评估，其疗效持续12小时。CB12对OLS的影响在夜间12小时也很明显（p = 0.0043）。CB12耐受性良好。总之，CB12对口腔内口臭显示出明确且持久的效果，白天和夜间至少持续12小时，对客观和主观变量均有一致效果。
