Wuerth Jennifer Deborah, Weber Friedemann
Institute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, Giessen 35392, Germany.
Viruses. 2016 Jun 22;8(6):174. doi: 10.3390/v8060174.
The genus Phlebovirus of the family Bunyaviridae contains a number of emerging virus species which pose a threat to both human and animal health. Most prominent members include Rift Valley fever virus (RVFV), sandfly fever Naples virus (SFNV), sandfly fever Sicilian virus (SFSV), Toscana virus (TOSV), Punta Toro virus (PTV), and the two new members severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus (HRTV). The nonstructural protein NSs is well established as the main phleboviral virulence factor in the mammalian host. NSs acts as antagonist of the antiviral type I interferon (IFN) system. Recent progress in the elucidation of the molecular functions of a growing list of NSs proteins highlights the astonishing variety of strategies employed by phleboviruses to evade the IFN system.
布尼亚病毒科白蛉病毒属包含许多新出现的病毒种类，对人类和动物健康都构成威胁。最著名的成员包括裂谷热病毒（RVFV）、那不勒斯白蛉热病毒（SFNV）、西西里白蛉热病毒（SFSV）、托斯卡纳病毒（TOSV）、蓬塔托罗病毒（PTV），以及两个新成员严重发热伴血小板减少综合征病毒（SFTSV）和哈特兰病毒（HRTV）。非结构蛋白NSs已被确认为哺乳动物宿主中主要的白蛉病毒毒力因子。NSs作为抗病毒I型干扰素（IFN）系统的拮抗剂。在阐明越来越多的NSs蛋白分子功能方面的最新进展凸显了白蛉病毒用于逃避IFN系统的惊人多样的策略。
