Beasley J M, Jung M, Tasevska N, Wong W W, Siega-Riz A M, Sotres-Alvarez D, Gellman M D, Kizer J R, Shaw P A, Stamler J, Stoutenberg M, Van Horn L, Franke A A, Wylie-Rosett J, Mossavar-Rahmani Y
1Department of Medicine,NYU School of Medicine,550 First Avenue,OBV-CD 673,New York,NY 10016,USA.
2Department of Epidemiology,Johns Hopkins School of Public Health,Baltimore,MD,USA.
Public Health Nutr. 2016 Dec;19(18):3256-3264. doi: 10.1017/S1368980016001580. Epub 2016 Jun 24.
Measurement error in self-reported total sugars intake may obscure associations between sugars consumption and health outcomes, and the sum of 24 h urinary sucrose and fructose may serve as a predictive biomarker of total sugars intake.
The Study of Latinos: Nutrition & Physical Activity Assessment Study (SOLNAS) was an ancillary study to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort. Doubly labelled water and 24 h urinary sucrose and fructose were used as biomarkers of energy and sugars intake, respectively. Participants' diets were assessed by up to three 24 h recalls (88 % had two or more recalls). Procedures were repeated approximately 6 months after the initial visit among a subset of ninety-six participants.
Four centres (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA) across the USA.
Men and women (n 477) aged 18-74 years.
The geometric mean of total sugars was 167·5 (95 % CI 154·4, 181·7) g/d for the biomarker-predicted and 90·6 (95 % CI 87·6, 93·6) g/d for the self-reported total sugars intake. Self-reported total sugars intake was not correlated with biomarker-predicted sugars intake (r=-0·06, P=0·20, n 450). Among the reliability sample (n 90), the reproducibility coefficient was 0·59 for biomarker-predicted and 0·20 for self-reported total sugars intake.
Possible explanations for the lack of association between biomarker-predicted and self-reported sugars intake include measurement error in self-reported diet, high intra-individual variability in sugars intake, and/or urinary sucrose and fructose may not be a suitable proxy for total sugars intake in this study population.
自我报告的总糖摄入量中的测量误差可能会掩盖糖消费与健康结果之间的关联，而24小时尿蔗糖和果糖的总和可能作为总糖摄入量的预测生物标志物。
拉丁裔研究：营养与身体活动评估研究（SOLNAS）是西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）队列的一项辅助研究。双标水和24小时尿蔗糖及果糖分别用作能量和糖摄入量的生物标志物。通过多达三次24小时回忆法评估参与者的饮食（88%的人有两次或更多次回忆）。在初次访视约6个月后，对96名参与者的一个子集重复进行这些程序。
美国的四个中心（纽约布朗克斯；伊利诺伊州芝加哥；佛罗里达州迈阿密；加利福尼亚州圣地亚哥）。
18至74岁的男性和女性（n = 477）。
生物标志物预测的总糖几何平均值为167.5（95%可信区间154.4, 181.7）克/天，自我报告的总糖摄入量为90.6（95%可信区间87.6, 93.6）克/天。自我报告的总糖摄入量与生物标志物预测的糖摄入量不相关（r = -0.06，P = 0.20，n = 450）。在可靠性样本（n = 90）中，生物标志物预测的总糖摄入量的再现性系数为0.59，自我报告的总糖摄入量的再现性系数为0.20。
生物标志物预测的和自我报告的糖摄入量之间缺乏关联的可能解释包括自我报告饮食中的测量误差、糖摄入量的高个体内变异性，和/或在本研究人群中尿蔗糖和果糖可能不是总糖摄入量的合适替代指标。
