Tetz George, Tetz Victor
Human Microbiology Institute, 303 5th Avenue, Suite 2012, New York, NY 10016 USA.
Gut Pathog. 2016 Jun 23;8:33. doi: 10.1186/s13099-016-0109-1. eCollection 2016.
Increased intestinal permeability and translocation of gut microbiota from the intestinal lumen to the systemic circulation predispose patients to various diseases and may be one of the main triggers thereof. The role of microbiota in increased intestinal permeability is under intensive investigation. Here, we studied alterations in the host and increased intestinal permeability as a direct effect of treatment with a bacteriophage cocktail. After 10 days of challenge, the rats showed weight loss, messy hair, and decreased activity. Additionally, they displayed a significantly elevated lactulose:mannitol ratio and the level of circulating immune complexes. To our knowledge, this study demonstrates for the first time that increased intestinal permeability may be induced by bacteriophages that affect the microbiota.
肠道通透性增加以及肠道微生物群从肠腔转移至体循环会使患者易患各种疾病，并且可能是这些疾病的主要触发因素之一。微生物群在肠道通透性增加中所起的作用正在深入研究中。在此，我们研究了用噬菌体混合物治疗的直接效应导致的宿主改变和肠道通透性增加。在攻击10天后，大鼠出现体重减轻、毛发凌乱和活动减少的情况。此外，它们的乳果糖：甘露醇比值和循环免疫复合物水平显著升高。据我们所知，本研究首次证明影响微生物群的噬菌体可能会诱导肠道通透性增加。
