Kau Hui-Chuan, Wu Shi-Bei, Tsai Chieh-Chih, Liu Catherine Jui-Ling, Wei Yau-Huei
Department of Ophthalmology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei 112, Taiwan; Department of Ophthalmology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei 112, Taiwan.
Department of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan.
Oxid Med Cell Longev. 2016;2016:4676289. doi: 10.1155/2016/4676289. Epub 2016 Jun 2.
Cigarette smoking is the most important risk factor for the development or deterioration of Graves' ophthalmopathy. Smoke-induced increased generation of reactive oxygen species may be involved. However, it remains to be clarified how orbital fibroblasts are affected by cigarette smoking. Our study demonstrated that Graves' orbital fibroblasts have exaggerated response to cigarette smoke extract challenge along with increased oxidative stress, fibrosis-related genes expression, especially connective tissue growth factor, and intracellular levels of transforming growth factor-β1 and interleukin-1β. The findings obtained in this study provide some clues for the impact of cigarette smoking on Graves' ophthalmopathy and offer a theoretical basis for the potential and rational use of antioxidants in treating Graves' ophthalmopathy.
吸烟是格雷夫斯眼病发生或恶化的最重要危险因素。烟雾诱导的活性氧生成增加可能与之有关。然而，吸烟如何影响眼眶成纤维细胞仍有待阐明。我们的研究表明，格雷夫斯眼眶成纤维细胞对香烟烟雾提取物刺激有过度反应，同时氧化应激增加、纤维化相关基因表达增加，尤其是结缔组织生长因子，以及细胞内转化生长因子-β1和白细胞介素-1β水平升高。本研究获得的结果为吸烟对格雷夫斯眼病的影响提供了一些线索，并为抗氧化剂在治疗格雷夫斯眼病中的潜在合理应用提供了理论依据。
