文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

用于平面样本中磁性粒子成像的混频磁检测扫描仪。

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples.

作者信息

Hong Hyobong, Lim Eul-Gyoon, Jeong Jae-Chan, Chang Jiho, Shin Sung-Woong, Krause Hans-Joachim

机构信息

Advanced Vision System Research Section, Electronics & Telecommunication Research Institute (ETRI);

Intelligent Cognitive Technology Research Department, Electronics & Telecommunication Research Institute (ETRI).

出版信息

J Vis Exp. 2016 Jun 9(112):53869. doi: 10.3791/53869.


DOI:10.3791/53869
PMID:27341085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4927779/
Abstract

The setup of a planar Frequency Mixing Magnetic Detection (p-FMMD) scanner for performing Magnetic Particles Imaging (MPI) of flat samples is presented. It consists of two magnetic measurement heads on both sides of the sample mounted on the legs of a u-shaped support. The sample is locally exposed to a magnetic excitation field consisting of two distinct frequencies, a stronger component at about 77 kHz and a weaker field at 61 Hz. The nonlinear magnetization characteristics of superparamagnetic particles give rise to the generation of intermodulation products. A selected sum-frequency component of the high and low frequency magnetic field incident on the magnetically nonlinear particles is recorded by a demodulation electronics. In contrast to a conventional MPI scanner, p-FMMD does not require the application of a strong magnetic field to the whole sample because mixing of the two frequencies occurs locally. Thus, the lateral dimensions of the sample are just limited by the scanning range and the supports. However, the sample height determines the spatial resolution. In the current setup it is limited to 2 mm. As examples, we present two 20 mm × 25 mm p-FMMD images acquired from samples with 1 µm diameter maghemite particles in silanol matrix and with 50 nm magnetite particles in aminosilane matrix. The results show that the novel MPI scanner can be applied for analysis of thin biological samples and for medical diagnostic purposes.

摘要

介绍了一种用于对扁平样品进行磁粒子成像(MPI)的平面频率混合磁检测(p-FMMD)扫描仪的设置。它由安装在U形支架腿上的位于样品两侧的两个磁测量头组成。样品局部暴露于由两个不同频率组成的磁激发场中,一个较强的分量约为77 kHz,一个较弱的场为61 Hz。超顺磁性颗粒的非线性磁化特性导致互调产物的产生。通过解调电子设备记录入射到磁性非线性颗粒上的高频和低频磁场的选定和频分量。与传统的MPI扫描仪相比,p-FMMD不需要对整个样品施加强磁场,因为两个频率的混合在局部发生。因此,样品的横向尺寸仅受扫描范围和支架的限制。然而,样品高度决定了空间分辨率。在当前设置中,它限制为2 mm。作为示例,我们展示了从硅烷醇基质中含有1 µm直径磁赤铁矿颗粒和氨基硅烷基质中含有50 nm磁铁矿颗粒的样品获得的两张20 mm×25 mm的p-FMMD图像。结果表明,这种新型MPI扫描仪可用于分析薄生物样品和用于医学诊断目的。

相似文献

[1]
Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples.

J Vis Exp. 2016-6-9

[2]
Magnetic particle imaging with a planar frequency mixing magnetic detection scanner.

Rev Sci Instrum. 2014-1

[3]
Magnetic immunoassay platform based on the planar frequency mixing magnetic technique.

Biosens Bioelectron. 2016-4-23

[4]
Multiplex Detection of Magnetic Beads Using Offset Field Dependent Frequency Mixing Magnetic Detection.

Sensors (Basel). 2021-8-31

[5]
Key Contributors to Signal Generation in Frequency Mixing Magnetic Detection (FMMD): An In Silico Study.

Sensors (Basel). 2024-3-18

[6]
Tomographic Field Free Line Magnetic Particle Imaging With an Open-Sided Scanner Configuration.

IEEE Trans Med Imaging. 2020-12

[7]
Frequency Mixing Magnetic Detection Setup Employing Permanent Ring Magnets as a Static Offset Field Source.

Sensors (Basel). 2022-11-14

[8]
MPI System with Bore Sizes of 75 mm and 100 mm Using Permanent Magnets and FMMD Technique.

Sensors (Basel). 2024-6-10

[9]
Construction of 3D-rendering imaging of an ischemic rat brain model using the planar FMMD technique.

Sci Rep. 2019-12-13

[10]
Electronic field free line rotation and relaxation deconvolution in magnetic particle imaging.

IEEE Trans Med Imaging. 2014-10-24

引用本文的文献

[1]
Fundamentals and Applications of Dual-Frequency Magnetic Particle Spectroscopy: Review for Biomedicine and Materials Characterization.

Adv Sci (Weinh). 2025-4

[2]
Comparative Modeling of Frequency Mixing Measurements of Magnetic Nanoparticles Using Micromagnetic Simulations and Langevin Theory.

Nanomaterials (Basel). 2021-5-11

[3]
Construction of 3D-rendering imaging of an ischemic rat brain model using the planar FMMD technique.

Sci Rep. 2019-12-13

本文引用的文献

[1]
Magnetic particle imaging with a planar frequency mixing magnetic detection scanner.

Rev Sci Instrum. 2014-1

[2]
Lymphatic Tissue and Superparamagnetic Nanoparticles - Magnetic Particle Imaging for Detection and Distribution in a Breast Cancer Model.

Biomed Tech (Berl). 2013-8

[3]
Magnetic particle imaging (MPI) for NMR and MRI researchers.

J Magn Reson. 2012-12-27

[4]
Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior.

Nat Methods. 2012-10-14

[5]
Magnetic particle imaging: visualization of instruments for cardiovascular intervention.

Radiology. 2012-9-20

[6]
X-space MPI: magnetic nanoparticles for safe medical imaging.

Adv Mater. 2012-7-24

[7]
Magnetic particle imaging: introduction to imaging and hardware realization.

Z Med Phys. 2012-8-19

[8]
Toward cardiovascular interventions guided by magnetic particle imaging: first instrument characterization.

Magn Reson Med. 2012-7-24

[9]
Fundamentals and applications of magnetic particle imaging.

J Cardiovasc Comput Tomogr. 2012-4-26

[10]
Projection x-space magnetic particle imaging.

IEEE Trans Med Imaging. 2012-5

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索