Barczak Wojciech, Golusiński Pawel, Luczewski Lukasz, Suchorska Wiktoria M, Masternak Michal M, Golusiński Wojciech
Department of Head and Neck Surgery, The Greater Poland Cancer Centre, Poznań University of Medical Sciences, Garbary 15 Str., 61-866, Poznan, Poland.
Radiobiology Lab, Department of Medical Physics, The Greater Poland Cancer Centre, Garbary 15 Str., 61-866, Poznan, Poland.
Biotechnol Lett. 2016 Oct;38(10):1665-72. doi: 10.1007/s10529-016-2163-7. Epub 2016 Jun 24.
Head and neck squamous cell carcinoma is the sixth leading cause of cancer worldwide. The most common risk factors are carcinogens (tobacco, alcohol), and infection of the human papilloma virus. Surgery is still considered as the treatment of choice in case of head and neck cancer, followed by a reconstructive surgery to enhance the quality of life in the patients. However, the widespread use of artificial implants does not provide appropriate physiological activities and often cannot act as a long-term solution for the patients. Here we review the applicability of multiple stem cell types for tissue engineering of cartilage, trachea, vocal folds and nerves for head and neck injuries. The ability of the cells to self-renew and maintain their pluripotency state makes them an attractive tool in tissue engineering.
头颈部鳞状细胞癌是全球第六大癌症死因。最常见的风险因素是致癌物（烟草、酒精）以及人乳头瘤病毒感染。对于头颈部癌症，手术仍被视为首选治疗方法，随后进行重建手术以提高患者的生活质量。然而，人工植入物的广泛使用并不能提供适当的生理活动，而且往往无法为患者提供长期解决方案。在此，我们综述了多种干细胞类型在头颈部损伤的软骨、气管、声带和神经组织工程中的适用性。细胞自我更新和维持其多能性状态的能力使其成为组织工程中有吸引力的工具。
