Vgr-1是一种与非洲爪蟾Vg-1相关的哺乳动物基因，属于转化生长因子β基因超家族的一员。

Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.

作者信息

Lyons K, Graycar J L, Lee A, Hashmi S, Lindquist P B, Chen E Y, Hogan B L, Derynck R

机构信息

Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080.

出版信息

Proc Natl Acad Sci U S A. 1989 Jun;86(12):4554-8. doi: 10.1073/pnas.86.12.4554.

The transforming growth factor beta (TGF-beta)-related products of the Xenopus Vg-1 and Drosophila decapentaplegic (DPP) genes have been implicated in the control of growth and differentiation during embryogenesis. We have isolated a mouse cDNA, Vgr-1, that encodes a polypeptide structurally related to Xenopus Vg-1. Sequence comparisons indicate that the Vgr-1 protein belongs to a family of DPP-like gene products within the TGF-beta superfamily. The levels of Vgr-1 RNA were determined in embryos and tissues isolated at various stages of development. A 3.5-kilobase mRNA increases throughout development and into adulthood in many tissues and in F9 teratocarcinoma cells differentiating into endoderm in response to retinoic acid and cAMP. The amino acid homologies and patterns of expression suggest that, like the DPP gene product, Vgr-1 plays a role at various stages of development.

非洲爪蟾Vg-1基因和果蝇的dpp（decapentaplegic）基因所产生的与转化生长因子β（TGF-β）相关的产物，已被证实参与胚胎发育过程中的生长和分化调控。我们分离出了一个小鼠cDNA，即Vgr-1，它编码一种在结构上与非洲爪蟾Vg-1相关的多肽。序列比较表明，Vgr-1蛋白属于TGF-β超家族中dpp样基因产物家族。我们测定了在发育各个阶段分离出的胚胎和组织中Vgr-1 RNA的水平。一种3.5千碱基的mRNA在许多组织以及在视黄酸和cAMP作用下分化为内胚层的F9畸胎瘤细胞中，在整个发育过程直至成年期都有所增加。氨基酸同源性和表达模式表明，与dpp基因产物一样，Vgr-1在发育的各个阶段都发挥作用。