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大脑中的寨卡病毒：新模型揭示病毒感染情况

Zika in the Brain: New Models Shed Light on Viral Infection.

作者信息

Hickman Heather D, Pierson Theodore C

机构信息

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Trends Mol Med. 2016 Aug;22(8):639-641. doi: 10.1016/j.molmed.2016.06.004. Epub 2016 Jun 23.

DOI:10.1016/j.molmed.2016.06.004
PMID:27345865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4990132/
Abstract

The current Zika virus (ZIKV) outbreak is associated with high numbers of human congenital birth defects, yet it has been unclear how ZIKV infection during pregnancy causes these abnormalities. Three new mouse models now show that ZIKV crosses the placenta and replicates in the brains of fetal mice.

摘要

当前的寨卡病毒（ZIKV）疫情与大量人类先天性出生缺陷有关，但尚不清楚孕期感染ZIKV如何导致这些异常情况。如今有三种新的小鼠模型表明，ZIKV可穿过胎盘并在胎鼠大脑中复制。

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Zika in the Brain: New Models Shed Light on Viral Infection.大脑中的寨卡病毒：新模型揭示病毒感染情况
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本文引用的文献

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The Brazilian Zika virus strain causes birth defects in experimental models.巴西寨卡病毒毒株在实验模型中会导致出生缺陷。
Nature. 2016 Jun 9;534(7606):267-71. doi: 10.1038/nature18296. Epub 2016 May 11.
2
Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise.小鼠孕期感染寨卡病毒会导致胎盘损伤和胎儿死亡。
Cell. 2016 May 19;165(5):1081-1091. doi: 10.1016/j.cell.2016.05.008. Epub 2016 May 11.
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Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.寨卡病毒扰乱神经祖细胞发育，导致小鼠小头畸形。
寨卡病毒概述：传播、起源、发病机制、动物模型及诊断
Zoonoses. 2021;1(1). doi: 10.15212/zoonoses-2021-0017. Epub 2021 Dec 7.
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Development and Expression of Subunit Vaccines Against Viruses in Plants.植物中抗病毒亚单位疫苗的开发与表达
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Sci Rep. 2019 Sep 5;9(1):12802. doi: 10.1038/s41598-019-49209-7.
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Viruses. 2018 Jan 22;10(1):49. doi: 10.3390/v10010049.
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