大脑中的寨卡病毒：新模型揭示病毒感染情况
Zika in the Brain: New Models Shed Light on Viral Infection.
作者信息
Hickman Heather D, Pierson Theodore C
机构信息
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Trends Mol Med. 2016 Aug;22(8):639-641. doi: 10.1016/j.molmed.2016.06.004. Epub 2016 Jun 23.
Abstract
The current Zika virus (ZIKV) outbreak is associated with high numbers of human congenital birth defects, yet it has been unclear how ZIKV infection during pregnancy causes these abnormalities. Three new mouse models now show that ZIKV crosses the placenta and replicates in the brains of fetal mice.
摘要
当前的寨卡病毒（ZIKV）疫情与大量人类先天性出生缺陷有关，但尚不清楚孕期感染ZIKV如何导致这些异常情况。如今有三种新的小鼠模型表明，ZIKV可穿过胎盘并在胎鼠大脑中复制。
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