免疫调节与生物材料在骨缺损修复过程中作为支架的作用：综述
The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review.
作者信息
Dong Changchao, Tan Gang, Zhang Guangyan, Lin Wei, Wang Guanglin
机构信息
Trauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Orthopedics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
出版信息
Front Bioeng Biotechnol. 2023 Mar 29;11:1133995. doi: 10.3389/fbioe.2023.1133995. eCollection 2023.
The process of bone regeneration involves the interaction of the skeletal, blood, and immune systems. Bone provides a solid barrier for the origin and development of immune cells in the bone marrow. At the same time, immune cells secrete related factors to feedback on the remodeling of the skeletal system. Pathological or traumatic injury of bone tissue involves changes in blood supply, cell behavior, and cytokine expression. Immune cells and their factors play an essential role in repairing foreign bodies in bone injury or implantation of biomaterials, the clearance of dead cells, and the regeneration of bone tissue. This article reviews the bone regeneration application of the bone tissue repair microenvironment in bone cells and immune cells in the bone marrow and the interaction of materials and immune cells.
骨再生过程涉及骨骼、血液和免疫系统的相互作用。骨骼为骨髓中免疫细胞的起源和发育提供了坚实的屏障。同时，免疫细胞分泌相关因子以反馈骨骼系统的重塑。骨组织的病理或创伤性损伤涉及血液供应、细胞行为和细胞因子表达的变化。免疫细胞及其因子在骨损伤中异物修复或生物材料植入、死细胞清除以及骨组织再生中起着至关重要的作用。本文综述了骨组织修复微环境在骨细胞和骨髓免疫细胞中的骨再生应用以及材料与免疫细胞的相互作用。
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