Hemmati Shiva, Seradj Hassan
Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, P. O. Box 71345-1583 Shiraz, Iran.
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, P. O. Box 71345-3119 Shiraz, Iran.
Molecules. 2016 Jun 23;21(7):820. doi: 10.3390/molecules21070820.
Adverse effects and drug resistance to the current onchopharmacologicals have increased the demand for alternative novel therapeutics. We herein introduce justicidin B, an arylnaphthalen lignan isolated from different plant origins, especially Justicia, Phyllanthus, Haplophyllum and Linum species. This cyclolignan exhibits a wide array of biological properties ranges from piscicidal to antifungal, antiviral and antibacterial activities. Activity against Trypanosoma brucei makes justicidin B a potential antiprotozoal agent for the treatment of neglected tropical diseases. Pharmacological properties like antiplatelet, anti-inflammatory and bone resorption inhibition have been also attributed to justicidin B. This compound is a potent cytotoxic substance on several cell lines, especially chronic myeloid and chronic lymphoid leukemia. Pharmacological values, natural variation, as well as biotechnological production of justicidin B by plant cell, tissue and organ culture are also described in this review. Chemical characteristics and chromatographic methods to identify justicidin B and its biosynthetic pathway have been discussed. Different approaches to the total synthesis of justicidin B are compared. This review would shed light on the role of justicidin B as an intriguing natural compound and provides a chance to optimize conditions for industrial applications.
当前抗寄生虫药物的不良反应和耐药性增加了对新型替代疗法的需求。我们在此介绍异紫堇定B，一种从不同植物来源分离得到的芳基萘木脂素，特别是爵床属、叶下珠属、单叶芸香属和亚麻属植物。这种环木脂素具有广泛的生物学特性，从杀鱼活性到抗真菌、抗病毒和抗菌活性。对布氏锥虫的活性使异紫堇定B成为治疗被忽视热带病的潜在抗原虫药物。异紫堇定B还具有抗血小板、抗炎和抑制骨吸收等药理特性。该化合物对多种细胞系具有强大的细胞毒性，尤其是慢性髓性白血病和慢性淋巴细胞白血病细胞系。本文还描述了异紫堇定B的药理价值、自然变异以及通过植物细胞、组织和器官培养进行生物技术生产的情况。讨论了鉴定异紫堇定B的化学特征和色谱方法及其生物合成途径。比较了异紫堇定B全合成的不同方法。这篇综述将阐明异紫堇定B作为一种有趣的天然化合物的作用，并为优化工业应用条件提供机会。
