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大麻二酚介导的金属纳米颗粒在人角质形成细胞中的绿色合成、表征及细胞毒性

Cannabidiol-Mediated Green Synthesis, Characterization, and Cytotoxicity of Metal Nanoparticles in Human Keratinocyte Cells.

作者信息

Josiah Andrea Jess, Pillai Sreejarani K, Cordier Werner, Nell Margo, Twilley Danielle, Lall Namrita, Ray Suprakas Sinha

机构信息

Centre for Nanostructured and Advanced Materials, DSI-CSIR Nanotechnology Innovation Centre, Council for Scientific and Industrial Research, Pretoria 0001, South Africa.

Department of Chemical Sciences, University of Johannesburg, Doornfontein, 2028 Johannesburg, South Africa.

出版信息

ACS Omega. 2021 Oct 21;6(43):29078-29090. doi: 10.1021/acsomega.1c04303. eCollection 2021 Nov 2.

DOI:10.1021/acsomega.1c04303
PMID:34746597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8567371/
Abstract

This study investigated a unique one-pot microwave-assisted green synthesis method of gold (Au) and silver (Ag) nanoparticles (NPs) using cannabidiol (CBD) as a capping and reducing agent. Furthermore, Au and Ag NPs were also chemically synthesized using poly(vinyl pyrrolidone), which functioned as reference materials when comparing the size, shape, and cytotoxicity of NPs. Synthesis parameters such as reaction time, temperature, and precursor molar ratio were optimized to control the size and shape of the biosynthesized NPs. Various characterization techniques such as transmission electron microscopy, ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction were used to confirm the formation and properties of Au and Ag NPs. Both biosynthesized metal NPs were spherical and monodispersed, with average particle sizes of 8.4 nm (Au-CBD) and 4.8 nm (Ag-CBD). This study also explored the potential cytotoxicity of CBD-capped NPs in human keratinocyte cells, which was observed to be of minimal concern. The novel synthesis approach presented in this study is free from harsh chemical reagents; therefore, these NPs can be used in a wide array of applications, including the pharmaceutical and biomedical fields.

摘要

本研究探究了一种独特的一锅法微波辅助绿色合成金（Au）和银（Ag）纳米颗粒（NPs）的方法，该方法使用大麻二酚（CBD）作为封端剂和还原剂。此外，还使用聚乙烯吡咯烷酮化学合成了Au和Ag NPs，在比较NPs的尺寸、形状和细胞毒性时用作参考材料。对反应时间、温度和前驱体摩尔比等合成参数进行了优化，以控制生物合成NPs的尺寸和形状。使用了各种表征技术，如透射电子显微镜、紫外可见光谱、傅里叶变换红外光谱和X射线衍射，来确认Au和Ag NPs的形成及性质。两种生物合成的金属NPs均为球形且单分散，平均粒径分别为8.4 nm（Au-CBD）和4.8 nm（Ag-CBD）。本研究还探究了CBD封端的NPs在人角质形成细胞中的潜在细胞毒性，结果显示其细胞毒性极小。本研究中提出的新型合成方法无需使用苛刻的化学试剂；因此，这些NPs可用于包括制药和生物医学领域在内的广泛应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/2a2a7ef2cafc/ao1c04303_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/bd2b691d6cc3/ao1c04303_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/dc52a05f3267/ao1c04303_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/10f185951678/ao1c04303_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/120403734eba/ao1c04303_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/0b8cc76f0a2f/ao1c04303_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/655be0d25174/ao1c04303_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/2a2a7ef2cafc/ao1c04303_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/bd2b691d6cc3/ao1c04303_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/dc52a05f3267/ao1c04303_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/10f185951678/ao1c04303_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/120403734eba/ao1c04303_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/0b8cc76f0a2f/ao1c04303_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/655be0d25174/ao1c04303_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3add/8567371/2a2a7ef2cafc/ao1c04303_0008.jpg

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