The efficacy and safety of subcision using CO gas combined with fractional laser for acne scars: Clinical and microscopic evaluation.

BACKGROUND

Various modalities have been used to treat acne scars. CO fractional laser is an effective and commonly used treatment. CO gas injection into the dermis by needle with high pressure can cause fibrotic collagen breakage, producing the effects of subcision. CO also stimulates collagen synthesis by increasing neovascularization and releasing oxygen.

OBJECTIVE

This study evaluated the efficacy and the safety of the combined treatment with CO gas subcision and CO fractional laser for acne scars.

METHODS AND MATERIALS

Fourteen patients with acne scars were treated with three sessions of CO gas subcision at 2-week intervals and two sessions of fractional laser at 4-week interval. The clinical improvement was assessed using a 4-point scale. For histologic analysis, punch biopsy was performed before and after treatment in 10 patients.

RESULTS

All patients experienced clinical improvements. Excellent, marked, moderate, and mild response was achieved in 1 (7%), 8 (57%), 4 (29%), and 1 patient (7%), respectively. Histologic evaluation of the biopsy specimens showed increased dermal collagen with dermal thickening and elastic fiber straightening in the reticular dermis after the treatment.

CONCLUSION

The combination therapy with CO gas subcision and fractional laser was satisfactory and safe for treating acne scars. Abbreviation and acronym: CO: Carbon dioxide GAS: Global assessment scale H&E: hematoxylin and eosin; SD: standard deviation.