Park Y C, Uchida A, Ohnishi N, Kiwamoto H, Esa A, Sugiyama T, Kaneko S, Kurita T
Department of Urology, Kinki University School of Medicine.
Hinyokika Kiyo. 1989 Mar;35(3):537-40.
TD-758 (12 mg tablets) was given in two tablets daily to 19 patients with nervous pollakisuria. The changes in frequency of daily micturition and in subjective symptoms were studied referring to the diary kept by each patient, along with the occurrence of side effects. Before the medication, urodynamic studies were made on each patient and all the cases were thus confirmed being free from detrusor instability or uninhibited contraction. The wash-out period of other drugs and control observation period, each one week, were set before the medication period which lasted for four weeks. The frequency of micturition per day showed a significant decrease from the first week of the medication period (p less than 0.05), and at the fourth week there was noted a significant reduction by twice per day on the average (p less than 0.001). Subjective efficacy was noted as follows: excellent in 3 cases (15.8%), good in 9 cases (47.7%), unchanged in 7 cases (36.8%), and thus 12 cases (63.2%) showed an efficacy of the rating of good or higher. In four cases dry mouth and in two cases sense of abdominal distention were noted out of the total of 19 cases, but no side effects of severe degree to stop the medication were noted during the medication period. In conclusion TD-758 is a clinically useful remedy for treatment of nervous pollakisuria.
将TD - 758（12毫克片剂）以每日两片的剂量给予19例神经性尿频患者。参照每位患者记录的日记，研究每日排尿频率和主观症状的变化，以及副作用的发生情况。在用药前，对每位患者进行了尿动力学研究，所有病例均被证实无逼尿肌不稳定或无抑制性收缩。在持续四周的用药期之前，设定了一周的其他药物洗脱期和一周的对照观察期。每日排尿频率从用药期第一周开始显著下降（p < 0.05），在第四周时平均每天显著减少两倍（p < 0.001）。主观疗效如下：3例（15.8%）为优，9例（47.7%）为良，7例（36.8%）无变化，因此12例（63.2%）显示疗效为良或更高。在19例患者中，4例出现口干，2例出现腹胀，但在用药期间未发现严重到需要停药的副作用。总之，TD - 758是治疗神经性尿频的一种临床有用的药物。
