Ishido T, Miyazaki K
Department of Urology, Kanagawa Prefecture General Rehabilitation Center, Kanagawa Rehabilitation Hospital.
Hinyokika Kiyo. 1988 Apr;34(4):754-8.
Terodiline HCl was administered in a long-term study to 20 patients with neurogenic bladder and pollakisuria. Its efficacy on urinary frequency and urinary incontinence was studied together with its safety and changes in blood concentration. The dosing period extended from 2 through 53 weeks (21 weeks on the average). The drug was found effective in 62% of diurnal urinary frequency patients, 71% of nocturnal urinary frequency, 73% of urinary incontinence, and 69% of nocturnal enuresis. Side effects of dizziness and nasal obstruction were seen in only one case. The drug was judged to be useful in 75% of the patients studied. Terodiline HCl showed no further increase in plasma concentration due to the long-term administration, and it disappeared from plasma within one to two months after the last dosing.
在一项长期研究中，对20例神经源性膀胱和尿频患者给予盐酸特罗地林。研究了其对尿频和尿失禁的疗效及其安全性和血药浓度变化。给药期从2周延长至53周（平均21周）。发现该药物对62%的日间尿频患者、71%的夜间尿频患者、73%的尿失禁患者和69%的夜间遗尿患者有效。仅1例出现头晕和鼻塞的副作用。在所研究的患者中，75%的患者认为该药物有用。长期给药后，盐酸特罗地林的血浆浓度未进一步升高，末次给药后1至2个月内从血浆中消失。
