Hann I M, Evans D I, Marsden H B, Jones P M, Palmer M K
J Clin Pathol. 1978 Apr;31(4):313-5. doi: 10.1136/jcp.31.4.313.
A prospective study of bone marrow fibrosis was made in a group of 40 children with acute lymphoblastic leukaemia to see whether it affected the prognosis or course of the disease. Secondary myelofibrosis (SMF) was present at diagnosis in 57% of the cases. It was not statistically significantly related to the prognosis or course of the disease. Thus, although trephine biopsy occasionally provided useful information in different diagnosis and when aspiration was difficult, it provided little information of use for management.
对一组40例急性淋巴细胞白血病患儿进行了骨髓纤维化的前瞻性研究，以观察其是否影响疾病的预后或病程。57%的病例在诊断时存在继发性骨髓纤维化（SMF）。它与疾病的预后或病程无统计学显著相关性。因此，尽管环钻活检偶尔在鉴别诊断及穿刺困难时能提供有用信息，但对治疗管理而言，其提供的有用信息很少。
