Oh Ji-Su, Cho In-A, Kang Kyeong-Rok, You Jae-Seek, Yu Sang-Joun, Lee Gyeong-Je, Seo Yo-Seob, Kim Chun Sung, Kim Do Kyung, Kim Su-Gwan, Seo Young-Woo, Im Hee-Jeong, Kim Jae-Sung
Department of Oral and Maxillofacial Surgery, Chosun University, Gwangju, 61452, Republic of Korea.
Department of Dental Bioengineering, Chosun University, Gwangju, 61452, Republic of Korea.
Biochem Biophys Res Commun. 2016 Sep 2;477(4):723-730. doi: 10.1016/j.bbrc.2016.06.126. Epub 2016 Jun 27.
Biochanin-A, a phytoestrogen derived from herbal plants, protected from the IL-1β-induced loss of proteoglycans through the suppression of matrix degrading enzymes such as matrix metalloproteinase (MMP)-13, MMP-3, MMP-1, and ADAMTS-5 in primary rat chondrocytes and the knee articular cartilage. It also suppressed the expression of IL-1β-induced catabolic factors such as nitric oxide synthase 2, cyclooxygenase-2, prostaglandin E2, and inflammatory cytokines. Furthermore, biochanin-A suppressed the IL-1β-induced phosphorylation of NFκB, and inhibited its nuclear translocation in primary rat chondrocytes. These results indicate that biochanin-A antagonizes the IL-1β-induced catabolic effects through its anti-inflammatory activity that involves the modulation of NFκB signaling.
生物chanin-A是一种源自草药植物的植物雌激素，通过抑制基质金属蛋白酶（MMP）-13、MMP-3、MMP-1和ADAMTS-5等基质降解酶以及在原代大鼠软骨细胞和膝关节软骨中抑制白细胞介素-1β诱导的蛋白聚糖损失。它还抑制白细胞介素-1β诱导的分解代谢因子如一氧化氮合酶2、环氧化酶-2、前列腺素E2和炎性细胞因子的表达。此外，生物chanin-A抑制白细胞介素-1β诱导的NFκB磷酸化，并抑制其在原代大鼠软骨细胞中的核转位。这些结果表明，生物chanin-A通过其涉及NFκB信号调节的抗炎活性拮抗白细胞介素-1β诱导的分解代谢作用。
