Ramachandran V G, Das Shukla, Roy Priyamvada, Hada Vivek, Mogha Narendra Singh
Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, 110095 India.
Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, 110095 India ; D-56, Block D, New Ashok Nagar, Delhi, 110096 India.
Virusdisease. 2016 Jun;27(2):183-6. doi: 10.1007/s13337-016-0314-z. Epub 2016 Apr 25.
Chikungunya fever is an important reemerging arbovirus illness, which is transmitted by the same vector as of dengue virus. Many cases of concurrent infections with multiple dengue virus serotypes have been reported in many countries. Also, concurrent infection with Chikungunya virus and dengue virus has been reported in the past in Delhi. Therefore, this study was done to detect Chikungunya IgM antibodies in suspected dengue fever patients. In this study, 1666 serum samples suspected of dengue fever and collected during the outbreak period (August 2010-December 2010) were tested for dengue IgM antibodies, of which 736 tested negative. Of the 736 dengue IgM negative sera, 666 were tested for Chikungunya IgM antibodies. The demographic profile and essential laboratory investigations were recorded. Chikungunya IgM was detected in 9.91 % of the patients. During the post-monsoon period though dengue dominated in numbers, the number of Chikungunya fever cases increased gradually followed by an abrupt decrease with the onset of winter. The Chikungunya IgM positive patients were suffering from fever of more than 5 days duration and had thrombocytopenia. Due to similarity in clinical features and vector transmitting dengue and Chikungunya virus, continuous surveillance of both dengue fever and Chikungunya fever is desirable for better management and epidemiological assessment.
基孔肯雅热是一种重要的再次出现的虫媒病毒疾病,它通过与登革病毒相同的媒介传播。许多国家都报告了多例感染多种登革病毒血清型的并发感染病例。此外,过去在德里也曾报告过基孔肯雅病毒和登革病毒的并发感染。因此,本研究旨在检测疑似登革热患者中的基孔肯雅IgM抗体。在本研究中,对2010年8月至2010年12月疫情暴发期间采集的1666份疑似登革热血清样本进行了登革IgM抗体检测,其中736份检测为阴性。在这736份登革IgM阴性血清中,666份进行了基孔肯雅IgM抗体检测。记录了人口统计学特征和必要的实验室检查结果。9.91%的患者检测出基孔肯雅IgM。在季风后时期,尽管登革热病例数量占主导,但基孔肯雅热病例数量逐渐增加,随后随着冬季的到来而突然下降。基孔肯雅IgM阳性患者发热持续超过5天,且有血小板减少症。由于登革热和基孔肯雅病毒的临床特征和传播媒介相似,为了更好地管理和进行流行病学评估,对登革热和基孔肯雅热进行持续监测是很有必要的。