Faculty of Biotechnology, University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland.
Department of Genetics, Plant Breeding and Seed Production, Faculty of Life Sciences and Technology, Wroclaw University of Environmental and Plant Sciences, Plac Grunwaldzki 24A, 53-363 Wroclaw, Poland.
Int J Mol Sci. 2016 Feb 18;17(2):160. doi: 10.3390/ijms17020160.
Phenolic compounds constitute a group of secondary metabolites which have important functions in plants. Besides the beneficial effects on the plant host, phenolic metabolites (polyphenols) exhibit a series of biological properties that influence the human in a health-promoting manner. Evidence suggests that people can benefit from plant phenolics obtained either by the diet or through skin application, because they can alleviate symptoms and inhibit the development of various skin disorders. Due to their natural origin and low toxicity, phenolic compounds are a promising tool in eliminating the causes and effects of skin aging, skin diseases, and skin damage, including wounds and burns. Polyphenols also act protectively and help prevent or attenuate the progression of certain skin disorders, both embarrassing minor problems (e.g., wrinkles, acne) or serious, potentially life-threatening diseases such as cancer. This paper reviews the latest reports on the potential therapy of skin disorders through treatment with phenolic compounds, considering mostly a single specific compound or a combination of compounds in a plant extract.
酚类化合物构成了一组次生代谢产物，它们在植物中具有重要的功能。除了对植物宿主有益的作用外，酚类代谢物（多酚）还表现出一系列生物特性，以促进健康的方式影响人类。有证据表明，人们可以从饮食或皮肤应用中获得植物酚类物质中受益，因为它们可以缓解症状并抑制各种皮肤疾病的发展。由于其天然来源和低毒性，酚类化合物是消除皮肤老化、皮肤疾病和皮肤损伤（包括伤口和烧伤）原因和影响的有前途的工具。多酚还具有保护作用，有助于预防或减轻某些皮肤疾病的进展，包括尴尬的小问题（如皱纹、粉刺）或严重的、潜在危及生命的疾病，如癌症。本文综述了通过使用酚类化合物治疗皮肤疾病的最新报告，主要考虑单一特定化合物或植物提取物中的化合物组合。
