发热性惊厥患儿血清锌水平。
Serum Zinc Level in Children Presenting with Febrile Seizures.
出版信息
Pak J Med Sci. 2013 Jul;29(4):1008-11.
OBJECTIVE
To determine the frequency of low serum zinc level in children presenting with febrile seizures at The Children's Hospital and the Institute of Child Health (CH/ICH) Multan.
METHODS
This is an observational cross sectional study conducted at the Department of Pediatric Medicine, The Children's Hospital and the Institute of Child Health, Multan from September 2010 to March 2011. Children (6 months to 6 years of age) presenting with febrile seizures who satisfied inclusion and exclusion criteria were enrolled for the study. Cause of fever was determined after detailed history, physical examination and relevant investigations. Four milliliters centrifuged blood sample was preserved in acid washed test tube. Separated serum was used to measure serum zinc level by employing Randox kit on auto-analyzer in all cases. The outcome variable (serum zinc level) was recorded on a predesigned proforma.
RESULTS
Out of 100 enrolled children, there were 66 (66%) male with male to female ratio of 1:0.52. Mean age of the children was 23.97±14.45 months. Upper respiratory tract infection was the most frequent cause of fever apparent in 24 children (24%) followed by tonsillitis 17 (17%), pneumonia 16 (16%), urinary tract infection 16 (16%), otitis media 15 (15%), and bronchiolitis 12 (12%). Frequency of low serum zinc level was 26% in children with febrile seizures.
CONCLUSION
Zinc deficiency could be a potential risk factor for febrile seizure in children.
目的
确定在巴基斯坦木尔坦儿童医院和儿童健康研究所（CH/ICH）就诊的热性惊厥患儿中血清锌水平低的频率。
方法
这是一项在木尔坦儿童医院和儿童健康研究所儿科医学系进行的观察性横断面研究。2010 年 9 月至 2011 年 3 月期间，纳入符合纳入和排除标准的热性惊厥患儿进行研究。在详细的病史、体格检查和相关检查后确定发热的原因。采集 4 毫升离心血样，保存在酸洗试管中。在所有病例中，均采用 Randox 试剂盒在自动分析仪上测量分离血清中的血清锌水平。将结果变量（血清锌水平）记录在预设计的表格上。
结果
在纳入的 100 名儿童中，有 66 名（66%）男性，男女比例为 1:0.52。儿童的平均年龄为 23.97±14.45 个月。上呼吸道感染是发热最常见的原因，见于 24 名儿童（24%），其次是扁桃体炎 17 名（17%）、肺炎 16 名（16%）、尿路感染 16 名（16%）、中耳炎 15 名（15%）和细支气管炎 12 名（12%）。热性惊厥患儿中血清锌水平低的频率为 26%。
结论
锌缺乏可能是儿童热性惊厥的潜在危险因素。
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