由生物燃料电池供电的可穿戴传感器系统用于检测汗液中的乳酸水平。
Wearable Sensor System Powered by a Biofuel Cell for Detection of Lactate Levels in Sweat.
作者信息
Garcia S O, Ulyanova Y V, Figueroa-Teran R, Bhatt K H, Singhal S, Atanassov P
机构信息
CFD Research Corporation, Huntsville, Alabama 35806, USA.
University of New Mexico, Albuquerque, New Mexico 87131, USA.
出版信息
ECS J Solid State Sci Technol. 2016;5(8):M3075-M3081. doi: 10.1149/2.0131608jss. Epub 2016 May 4.
An NAD-dependent enzymatic sensor with biofuel cell power source system for non-invasive monitoring of lactate in sweat was designed, developed, and tested. The sensor component, based on lactate dehydrogenase, showed linear current response with increasing lactate concentrations with limits of detection from 5 to 100 mM lactate and sensitivity of 0.2 µA.mM in the presence of target analyte. In addition to the sensor patch a power source was also designed, developed and tested. The power source was a biofuel cell designed to oxidize glucose via glucose oxidase. The biofuel cell showed excellent performance, achieving over 80 mA at 0.4 V (16 mW) in a footprint of 3.5 × 3.5 × 0.7 cm. Furthermore, in order to couple the sensor to the power source, system electronic components were designed and fabricated. These consisted of an energy harvester (EH) and a micropotentiostat (MP). The EH was employed for harvesting power provided by the biofuel cell as well as up-converting the voltage to 3.0 V needed for the operation of the MP. The sensor was attached to MP for chronoamperometric detection of lactate. The Sensor Patch System was demonstrated under laboratory conditions.
设计、开发并测试了一种带有生物燃料电池电源系统的NAD依赖性酶传感器，用于无创监测汗液中的乳酸。基于乳酸脱氢酶的传感器组件在存在目标分析物的情况下，随着乳酸浓度的增加呈现线性电流响应，检测限为5至100 mM乳酸，灵敏度为0.2 μA·mM。除了传感器贴片外，还设计、开发并测试了一个电源。该电源是一个生物燃料电池，旨在通过葡萄糖氧化酶氧化葡萄糖。该生物燃料电池表现出优异的性能，在3.5×3.5×0.7 cm的占地面积内，在0.4 V（16 mW）时实现了超过80 mA的电流。此外，为了将传感器与电源耦合，设计并制造了系统电子元件。这些元件包括一个能量采集器（EH）和一个微电位计（MP）。EH用于采集生物燃料电池提供的电力，并将电压上转换为MP运行所需的3.0 V。传感器连接到MP上，用于乳酸的计时电流检测。该传感器贴片系统在实验室条件下得到了验证。
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