Zhu Yanfang Peipei, Thomas Graham D, Hedrick Catherine C
From the Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA.
Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1722-33. doi: 10.1161/ATVBAHA.116.304054. Epub 2016 Jul 7.
Monocytes and macrophages are key immune cells involved in the early progression of atherosclerosis. Transcription factors that control their development in the bone marrow are important therapeutic targets to control the numbers and functions of these cells in disease. This review highlights what is currently known about the transcription factors that are critical for monocyte development.
单核细胞和巨噬细胞是参与动脉粥样硬化早期进展的关键免疫细胞。控制它们在骨髓中发育的转录因子是控制疾病中这些细胞数量和功能的重要治疗靶点。本综述重点介绍了目前已知的对单核细胞发育至关重要的转录因子。